51341-27-6Relevant academic research and scientific papers
Synthesis of carborane-containing carbonates via CO2 addition to epoxides
Cherkasova, Polina V.,Chowdhury, Biswajit,Korlyukov, Alexander A.,Lyubimov, Sergey E.,Olshevskaya, Valentina A.,Zaitsev, Andrei V.,Zvinchuk, Anastasia A.
, (2021/08/16)
A new method for the synthesis of carborane-containing carbonates by the reaction of CO2 with the corresponding epoxides was developed. The reaction can be facilitated by an additional hydroxyl group in the catalyst. The crystal structure of 1-phenyl-2-(1,3-dioxolan-2-onylmethyl)-C2B10H10 was determined by single crystal X-ray diffraction. The carborane-containing carbonates can be considered as precursors for the synthesis of advanced heat- and impact-resistant polycarbonates and agents for boron neutron capture therapy.
Tumour-targetted Boranes. Part 2. Coupling of closo-Carboranes to Substituted 2-Nitroimidazoles via 1,3-Dipolar Cycloaddition
Scobie. Martin,Mahon, Mary F.,Threadgill, Michael D.
, p. 203 - 210 (2007/10/02)
Carboranes targetted to specific tumour tissues are important for boron neutron capture therapy of cabcer.Direct syntheses of carboranes linked to 2-nitroimidazole were unsuccesful.A mild procedure for 1,3-dipolar cycloaddition of 4-(carboranylmethoxy)benzonitrile N-oxide 32 with a nitroimidazolyl-alkene 27 and with nitroimidazolyl-alkynes 3 and 30 has been developed, using a series of model reactions, yielding a dihydroisixazole 28 and the isoxazole 29 and 31, respectively.The nitrile oxide 32 is unusually stable.Dithioacetals are shown to be suitable protecting groups for aromatic aldehydes under the vigorous reductive and Lewis acidic-basic conditions of carborane formation. 6-Methoxy-4H-benzopyranoisoxazole 16 has been synthesised by intramolecular 1,3-dipolar cycloaddition.The structure of the isoxasole derivative 29 has been confirmed by an X-ray crystal structure analysis.
