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Icosanamide, also known as eicosanamide, is a long-chain primary fatty acid amide with 20 carbon atoms. It is a bioactive lipid that has been found in various natural sources such as the skin and milk of mammals, as well as some plants and marine organisms. Icosanamide has been studied for its potential anti-inflammatory, anti-cancer, and neuroprotective properties. It has been shown to interact with the endocannabinoid system in the body, and may have potential therapeutic applications in conditions such as pain, inflammation, and neurological disorders. Additionally, icosanamide has been investigated for its role in skin barrier function and hydration. Overall, icosanamide has shown promise for various biomedical and cosmetic applications, and continues to be the subject of research for its potential therapeutic benefits.

51360-63-5

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51360-63-5 Usage

Uses

Used in Pharmaceutical Industry:
Icosanamide is used as an anti-inflammatory agent for its potential to reduce inflammation and alleviate pain. It is also used as an anti-cancer agent for its potential to inhibit tumor growth and progression.
Used in Neurological Disorders:
Icosanamide is used as a neuroprotective agent for its potential to protect neurons and reduce the severity of neurological disorders.
Used in Cosmetic Industry:
Icosanamide is used as a skin barrier function enhancer for its potential to improve skin hydration and maintain skin health.
Used in Endocannabinoid System Research:
Icosanamide is used as a research compound for its potential interaction with the endocannabinoid system, which may have therapeutic applications in various conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 51360-63-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,3,6 and 0 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 51360-63:
(7*5)+(6*1)+(5*3)+(4*6)+(3*0)+(2*6)+(1*3)=95
95 % 10 = 5
So 51360-63-5 is a valid CAS Registry Number.
InChI:InChI=1/C20H41NO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H2,21,22)

51360-63-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name icosanamide

1.2 Other means of identification

Product number -
Other names EINECS 257-152-8

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:51360-63-5 SDS

51360-63-5Relevant academic research and scientific papers

STERILE/ANTIBACTERIAL COMPOSITION

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Paragraph 0434, (2017/01/31)

DISCLOSED IS A STERILE/ANTIBACTERIAL COMPOSITION, A LIQUID DETERGENT COMPOSITION OR A COMPOSITION FOR TREATING A FIBER PRODUCT, WHICH COMPRISES A MIXTURE OF COMPONENTS (A1) AND (B1) OR A COMPLEX FORMED BY THE COMPONENTS (A1) AND (B1), WHEREIN THE COMPONENT (A1) IS A WATER-SOLUBLE SILVER SALT, A WATER-SOLUBLE COPPER SALT OR A WATER-SOLUBLE ZINC SALT AND THE COMPONENT (B1) IS AT LEAST ONE LONG-CHAIN ALKYLAMINE COMPOUND SELECTED FROM A COMPOUND REPRESENTED BY GENERAL FORMULA (I) AND A COMPOUND REPRESENTED BY GENERAL FORMULA (II) AND/OR AN ANION PRODUCED FROM THE LONG-CHAIN ALKYLAMINE COMPOUND. IN FORMULA (I), R1 REPRESENTS AN ALKYL GROUP HAVING 8 TO 22 CARBON ATOMS; A1 REPRESENTS A HYDROGEN ATOM OR (CH?)m,-COOX2; X1 AND X2 INDEPENDENTLY REPRESENT A HYDROGEN ATOM, AN ALKALI METAL ATOM, AN ALKALI EARTH METAL ATOM, OR A CATIONIC AMMONIUM GROUP; N REPRESENTS A NUMBER OF 1 TO 3; AND M REPRESENTS A NUMBER OF 1 TO 3. IN FORMULA (II), R2 REPRESENTS AN ALKYL OR ACYL GROUP HAVING 8 TO 22 CARBON ATOMS; Q REPRESENTS (NH-(CH?)m); R REPRESENTS A NUMBER OF 1 OR 0, PROVIDED THAT A2 AND A3 INDEPENDENTLY REPRESENT A HYDROGEN ATOM OR A METHYL GROUP WHEN R REPRESENTS 0, AND A2 REPRESENTS A HYDROGEN ATOM AND A3 REPRESENTS A HYDROGEN ATOM OR CH?COOX3 WHEN R REPRESENTS 1; X3 REPRESENTS A HYDROGEN ATOM, AN ALKALI METAL ATOM, AN ALKALI EARTH METAL ATOM OR A CATIONIC AMMONIUM GROUP; N REPRESENTS A NUMBER OF 1 TO 3; AND M REPRESENTS A NUMBER OF 1 TO 3.

Method and apparatus for manufacturing carboxylic acid amide compound

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Paragraph 0059-0062; 0068, (2017/06/02)

The present invention relates to a process and an apparatus for producing a carboxylic acid amide compound, and more particularly, to a process for producing a carboxylic acid amide compound which alternately performs a reaction process of a first manufacturing process that promotes the reaction between a first carboxylic acid and a first ammonia in the presence of a first catalyst and a reaction process of a second manufacturing process that promotes the reaction between a second carboxylic acid and a first ammonia in the presence of a second catalyst wherein each of them is progressed alternately between each preparation process so that the reaction between the carboxylic acid and the ammonia, which is intermittently carried out by the respective preparation processes, can be continuously performed, and moreover, the time required for the respective preparation processes is shortened, so that the carboxylic acid amide compound can be produced in a large amount in a short time.

Electrospray ionization and collision induced dissociation mass spectrometry of primary fatty acid amides

Divito, Erin B.,Davic, Andrew P.,Johnson, Mitchell E.,Cascio, Michael

, p. 2388 - 2394 (2012/07/27)

Primary fatty acid amides are a group of bioactive lipids that have been linked with a variety of biological processes such as sleep regulation and modulation of monoaminergic systems. As novel forms of these molecules continue to be discovered, more emphasis will be placed on selective, trace detection. Currently, there is no published experimental determination of collision induced dissociation of PFAMs. A select group of PFAM standards, 12 to 22 length carbon chains, were directly infused into an electrospray ionization source Quadrupole Time of Flight Mass Spectrometer. All standards were monitored in positive mode using the [M + H]+ peak. Mass Hunter Qualitative Analysis software was used to calculate empirical formulas of the product ions. All PFAMs showed losses of 14 m/z indicative of an acyl chain, while the monounsaturated group displayed neutral losses corresponding to H2O and NH3. The resulting spectra were used to propose fragmentation mechanisms. Isotopically labeled PFAMs were used to validate the proposed mechanisms. Patterns of saturated versus unsaturated standards were distinctive, allowing for simple differentiation. This determination will allow for fast, qualitative identification of PFAMs. Additionally, it will provide a method development tool for selection of unique product ions when analyzed in multiple reaction monitoring mode.

Lizard epidermal gland secretions. II. Chemical characterization of the generation gland secretion of the sungazer, cordylus giganteus

Louw, Stefan,Burger, Ben V.,Le Roux, Maritha,Van Wyk, Johannes H.

, p. 1364 - 1369 (2011/08/09)

In lizards, the epidermal glands of the femoral and precloacal regions are involved in the production of semiochemicals. In addition to its femoral glands, the giant girdled lizard, or sungazer, Cordylus giganteus, which is endemic to South Africa, has generation glands as an additional potential source of semiochemicals. These epidermal glands are described as glandular scales that overlay the femoral glands and are included in the normal epidermal profile located in the femoral (thigh) and anterior antebrachial (fore-leg) regions of the male sungazer. GC-MS analysis of the generation gland secretions and the trimethylsilyl derivatives of some of the steroidal constituents was employed to identify 59 constituents, including alkenes, carboxylic acids, alcohols, ketones, aldehydes, esters, amides, nitriles, and steroids. The quantitative differences of the volatile constituents of the fore- and hind-leg generation glands were compared between individuals. This is the first report on the chemical composition of generation glandular material of lizards.

Effect of cosolvent on the lateral order of spontaneously formed amphiphilic amide two-dimensional crystallites at the air-solution interface

Weinbach, Susan P.,Jacquemain, Didier,Leveiller, Franck,Kjaer, Kristian,Als-Nielsen, Jens,Leiserowitz, Leslie

, p. 11110 - 11118 (2007/10/02)

At low temperature (5-12 °C), uncompressed films of insoluble amphiphilic molecules C19H39X, where the head group X contains one (CONH2, 1) or two (CONHC2H4CONH2, 2) amide groups, spontaneously form two-dimensional (2D) crystalline clusters over aqueous subphases containing soluble amide or carboxylic acid molecules. These crystallites were detected and their structures were studied using grazing incidence X-ray diffraction (GID). In the presence of subphases containing carboxylic acid (RCO2H, R = H, CH2Cl) at sufficiently high concentrations, a loss of diffraction signal was observed for 1, while amide and less concentrated acid subphases did not show such a destructive effect. The effect of the subphase solute molecules was understood in terms of the different ways in which the solutes hydrogen bond to the amide head groups of the amphiphiles. Both amide and acid solute molecules can form hydrogen-bonded cyclic dimers with the amide head groups. With an amide subphase, such dimers lead to an extension of the hydrogen-bonding network of the crystallites, and thus enhance its stability, but acid molecules may also bind to the monolayer at low concentrations with less than full occupancy. At high acid concentration, and thus more extensive formation of cyclic dimers between carboxylic acid and amphiphilic amide molecules, repulsive interactions between lone pair electrons on oxygen atoms of bound acid molecules inhibit formation of ordered arrays of these dimers and lead to a lack of diffraction signal. In 2, the second amide group strengthens the crystallites to the extent that there is no decrease in crystallinity over a 1 M formic acid subphase. The shape of the intensity profiles of the Bragg rods and the specular X-ray reflectivity measurements of 2 indicate formation of molecular trilayers.

Mixed Monolayers for the Design of Structured Surfaces To Induce Oriented 3-D Crystallization

Weissbuch, I.,Majewski, J.,Kjaer, K.,Als-Nielsen, J.,Lahav, M.,Leiserowitz, L.

, p. 12848 - 12857 (2007/10/02)

Mixed monolayers containing two different amphiphiles C19H39CONHCH2CH2CO2H(A) and C19H39CONH2(B) were designed in order to form a two-dimensional (2-D) crystalline solid solution in which the A-type molecules form domains within the sea of B-type molecules.A "continuous" 2-D arrangement of the aliphatic chains was expected, driven by the amide hydrogen bonding requirement; a tendency for the formation of the embeded A-type domains should be provided by the interactions between the -CH2CH2CO2H head group moieties.The mixed monolayers served to promote the oriented nucleation of silver propionate 3-D crystals attached at the monolayer-solution interface.Only the A-type domains induced silver propionate crystallization whereas the B-type domains were essentially inert.The mixed A + B monolayers were found to be efficient nucleators down to a 1:10 molar ratio, providing proof for the existence of A-type domains.Additional information such as the structure and ion-binding properties of the mixed monolayers was furnished by specular X-ray reflectivity and grazing incidence X-ray diffraction using synchrotron radiation.

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