51361-17-2Relevant articles and documents
Potassium channel openers
-
, (2008/06/13)
Compounds of formula I: are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
New Derivatives of Asymmetic Chloral Aminals.
Barczynski,Eckstein
, p. 176 - 177 (2007/10/09)
This paper is concerned by newly developed fungicides. In the reported research program, first there were prepared parent carboxylic acids of benodanil, mebenil, furcarbanil, pyracarbolid, carboxin and G-696. Then they were transformed into respective amides. From the latter, by action of chloral, its semiaminals were obtained. Under analogous conditions, for the purpose of comparison in future tests on biological activity, chloral semiaminals were prepared from amides of the following acids: phenylthio - and phenylsulfoacetic, 3-(2 prime -chlorophenyl) - and 3-(2 prime ,6 prime -dichlorophenyl) - 5 -methylisoxazolcarboxylic-4. By action of phenyl isocyanate, 4-chlorophenyl and 3,4-dichlorophenyl on all chloral semiaminals synthesized respective asymmetric aminals of this aldehyde were obtained. The above reactions run with carbon dioxide elimination and give high yields of products.