51362-50-6

Basic information

• Product Name: 2-(4-CHLOROPHENOXY)PYRIDINE-3-CARBONYL CHLORIDE
• Synonyms: 2-(4-CHLOROPHENOXY)-2-PYRIDINE-3-CARBONYL CHLORIDE;2-(4-CHLOROPHENOXY)PYRIDINE-3-CARBONYL CHLORIDE;BUTTPARK 52\14-87;2-(4-Chloro-phenoxy)-nicotinoyl chloride
• CAS NO: 51362-50-6
• Molecular Formula: C12H7Cl2NO2
• Molecular Weight: 268.1
• Mol File: 51362-50-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 79 °C
• Boiling Point: 369.7°Cat760mmHg
• Flash Point: 177.4°C
• Appearance: /
• Density: 1.399g/cm³
• Vapor Pressure: 1.17E-05mmHg at 25°C
• Refractive Index: 1.604
• PKA: 0.01±0.22(Predicted)
• CAS DataBase Reference: 2-(4-CHLOROPHENOXY)PYRIDINE-3-CARBONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-CHLOROPHENOXY)PYRIDINE-3-CARBONYL CHLORIDE(51362-50-6)
• EPA Substance Registry System: 2-(4-CHLOROPHENOXY)PYRIDINE-3-CARBONYL CHLORIDE(51362-50-6)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: 3261
• Hazardous Substances Data: 51362-50-6(Hazardous Substances Data)

Usage

General Description

2-(4-Chlorophenoxy)pyridine-3-carbonyl chloride is a chemical compound with the formula C12H8ClNO2. It is a pyridine derivative with a carbonyl chloride functional group, and a chlorine atom attached to the phenyl ring. 2-(4-CHLOROPHENOXY)PYRIDINE-3-CARBONYL CHLORIDE is typically used as a building block in organic synthesis, particularly in the production of pharmaceuticals, agrochemicals, and other fine chemicals. It has been reported to exhibit pesticidal and herbicidal activity, and it is also used as an intermediate in the synthesis of various biologically active compounds. Due to its reactive nature, it is important to handle this compound with proper safety precautions and under controlled conditions.

InChI:InChI=1/C12H7Cl2NO2/c13-8-3-5-9(6-4-8)17-12-10(11(14)16)2-1-7-15-12/h1-7H

Upstream product

• 106-48-9 4-chloro-phenol 
• 2942-59-8 2-chloronicotinic acid 
• 51362-37-9 2-(4-chlorophenoxy)nicotinic acid 

Downstream Products

• 639514-61-7 C₂₁H₂₀ClN₃O₄S 
• 639514-51-5 C₂₁H₁₉ClN₂O₄S 

Relevant articles and documents

Design, Synthesis, and Herbicidal Activity of Novel Diphenyl Ether Derivatives Containing Fast Degrading Tetrahydrophthalimide

To seek new protoporphyrinogen oxidase (PPO) inhibitors with better biological activity, a series of novel diphenyl ether derivatives containing tetrahydrophthalimide were designed based on the principle of substructure splicing and bioisomerization. PPO inhibition experiments exhibited that 6c is the most potential compound, with the half-maximal inhibitory concentration (IC50) value of 0.00667 mg/L, showing 7 times higher activity than Oxyfluorfen (IC50 = 0.0426 mg/L) against maize PPO and similar herbicidal activities to Oxyfluorfen in weeding experiments in greenhouses and field weeding experiments. In view of the inspected bioactivities, the structure-activity relationship (SAR) of this series of compounds was also discussed. Crop selection experiments demonstrate that compound 6c is safe for soybeans, maize, rice, peanuts, and cotton at a dose of 300 g ai/ha. Accumulation analysis experiments showed that the accumulation of 6c in some crops (soybeans, peanuts, and cotton) was significantly lower than Oxyfluorfen. Current work suggests that compound 6c may be developed as a new herbicide candidate in fields.