51370-01-5

Basic information

• Product Name: 1-(isoquinolin-1-yl)butan-1-one
• Synonyms: 1-(isoquinolin-1-yl)butan-1-one
• CAS NO: 51370-01-5
• Molecular Weight: 199.252
• Mol File: 51370-01-5.mol

Chemical Properties

• CAS DataBase Reference: 1-(isoquinolin-1-yl)butan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(isoquinolin-1-yl)butan-1-one(51370-01-5)
• EPA Substance Registry System: 1-(isoquinolin-1-yl)butan-1-one(51370-01-5)

Safety Data

• Hazardous Substances Data: 51370-01-5(Hazardous Substances Data)

Upstream product

• 119-65-3 isoquinoline 
• 123-72-8 butyraldehyde 

Relevant articles and documents

Radical C?H Acylation of Nitrogen Heterocycles Induced by an Aerobic Oxidation of Aldehydes

An aerobic radical approach for the synthesis of unsymmetrical heteroaryl ketones is described herein. The reaction involves cross-dehydrogenative coupling between aldehydes and heteroaromatic bases with molecular oxygen (O2). The key aspect of the method is the generation of reactive acyl radical via homolytic activation of aldehyde C?H bond using O2 as the sole oxidant. The reaction has a good substrate scope with respect to aldehydes and functionalized nitrogen heterocycles. Based on our mechanistic studies, a radical chain pathway is suggested for the reaction. A synthetic application of the method is demonstrated in the formal synthesis of natural alkaloid (±) angustureine.

Dioxygen-Mediated Decarbonylative C-H Alkylation of Heteroaromatic Bases with Aldehydes

An operationally simple and economical method for the direct alkylation of heteroaromatic bases employing readily available aldehydes as alkyl radical precursors and molecular oxygen as a reagent is presented. This simple transformation demonstrates a broad substrate scope with respect to aldehydes and nitrogen heterocycles, enabling the introduction of several medicinally important yet challenging alkyl moieties, such as ethyl, isopropyl, tert-butyl, and cyclohexyl to the different classes of heterocyclic bases in good to excellent yields. A simple method for the direct alkylation of heteroaromatic bases with aldehydes as inexpensive alkyl radical precursors and molecular oxygen as a reagent is presented. This transformation demonstrates a broad substrate scope with respect to aldehydes and nitrogen heterocycles, enabling the introduction of various alkyl moieties to heterocyclic bases (>40 examples) in good to excellent yields.