51395-52-9Relevant academic research and scientific papers
Cascade assembling of pyrazolin-5-ones and benzylidenemalononitriles: The facile and efficient approach to medicinally relevant spirocyclopropylpyrazolone scaffold
Vereshchagin, Anatoly N.,Elinson, Michail N.,Korshunov, Aleksander D.,Korolev, Victor A.,Egorov, Mikhail P.
, p. 355 - 360 (2015/12/24)
A new cascade reaction provides a direct transformation of pyrazolin-5-ones and benzylidene-malononitriles by the action of bromine into substituted spirocyclopropylpyrazolones in 60-88% yields. This process can be realized in two variants, namely, (1) by treatment with bromine in the presence of base and (2) by treatment with bromine only with heating. These facile and efficient one-step cascade processes lead to the spirocyclopropylpyrazolone framework, which is present in a perspective class of compounds with prominent pharmacological and physiological activity.
Monobromomalononitrile: An efficient regioselective mono brominating agent towards active methylene compounds and enamines under mild conditions
Pathak, Sudipta,Kundu, Ashis,Pramanik, Animesh
, p. 10180 - 10187 (2014/03/21)
The potential of monobromomalononitrile (MBM) as a convenient source of cationic bromine in organic bromination reaction has been explored. Studies reveal that MBM can be a good substitute for N-bromosuccinimide (NBS) in various respects. Enamines and act
REACTIONS WITH NITRILES: A NOVEL SYNTHESIS OF FUROPYRAZOLES AND PYRANOPYRAZOLES
Aziz, Suzan I.,Abd-Allah, Sanaa O.,Ibrahim, Nadia S.
, p. 2523 - 2527 (2007/10/02)
Several new furopyrazole and pyranopyrazole derivatives were synthesized via the reaction of the 4-bromo-2-pyrazolin-5-one derivative 1 with activated nitriles and their ylidene derivatives.The synthesized products were established based on
