514-47-6

Basic information

• Product Name: euphol
• Synonyms: Lanosta-8,24-dien-3-ol,(3b,13a,14b,17a)-;euphol;Euphol, Euphadienol;(13α,14β,17α)-5α-Lanosta-8,24-dien-3β-ol;Euphadienol;alpha-Eupho
• CAS NO: 514-47-6
• Molecular Formula: C30H50O
• Molecular Weight: 426.724
• Mol File: 514-47-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 116-117℃
• Boiling Point: 498.9°Cat760mmHg
• Flash Point: 221.1°C
• Appearance: /
• Density: 0.98±0.1 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 4.83E-12mmHg at 25°C
• Refractive Index: 1.53
• PKA: 15.16±0.70(Predicted)
• CAS DataBase Reference: euphol(CAS DataBase Reference)
• NIST Chemistry Reference: euphol(514-47-6)
• EPA Substance Registry System: euphol(514-47-6)

Safety Data

• Hazardous Substances Data: 514-47-6(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 514-47-6 differently. You can refer to the following data:
1. antineoplastic, antiproliferative, antiinflammatory, antinociceptive
2. Euphadienol is an alcohol tetracyclic triterpene which is considered to have anti-inflammatory action. Oral administration of euphadienol consistently reduces and limits the severity and development of experimental autoimmune encephalomyelitis (EAE) which is an established model of Multiple sclerosis (MS). Euphadienol has been found to inhibit various autonomic pressor and depressor responses in dogs and rats.

InChI:InChI=1/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22+,25+,26+,28-,29+,30-/m1/s1

Upstream product

• 5539-04-8 lanostenone-3 
• 64-17-5 ethanol 
• 50719-45-4 24-bromo-euphadien-(8.24)-ol-(3β) 
• 14050-42-1 2,3-Oxidosqualene 

Downstream Products

• 2671-68-3 euphol acetate 
• 106766-75-0 eupha-8,24-dien-3-one-(2,4-dinitro-phenylhydrazon); euphone-(2,4-dinitro-phenylhydrazone) 
• 54411-45-9 euphene-(8)-dione-(7.11) 
• 1724-19-2 Tirucall-8-enyl-acetat 
• 38602-31-2 Euph-8-enylacetat 
• 35963-37-2 (22R)-3β,22-Dihydroxylanosta-8,24-diene 
• 2671-68-3 euphol acetate 
• 13879-05-5 3β-benzoyloxy-eupha-8,24-diene 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF LANOSTA-8-ENE COMPOU

The present invention concerns a process for the preparation of lanosta-8-ene compounds having lanosta-8-ene-7-one or lanosta-8-ene-7-ol compounds as starting material.

Une voie d'acces a la trimethyl-4,4,7a tetrahydro-3aα,4,7,7aα (3H)-benzofurannone-2 a partir des alcoxy-5 trimethyl-4,4,7a hexahydro-3aα,4,5,6,7,7aα (3H)-benzofurannones-2

The 5-hydroxy 4,4,7a-trimethyl 3aα, 4,5,6,7,7aα-hexahydro (3H)-benzofuran-2-ones are obtained by cleavage of the corresponding methyl or ethyl ethers with iodotrimethylsilane.The two hydroxylactones 5 and 6 are transformed into sulfonic esters as a step towards the dehydrated lactone 7, without squeletal rearrangement.Solvolysis of the tosylate and the mesylate of 5, a cis-fused ring lactone, proceeds by completely different ways under analogous experimental procedures.Results are explained and compared to the solvolysis of some triterpenes.Experimental procedures for ether cleavage are discussed and the intermediates or by-products of these reactions are identified.