51409-75-7

Basic information

• Product Name: 3-[(4-hydroxyphenyl)amino]cyclohex-2-en-1-one
• Synonyms: 3-[(4-hydroxyphenyl)amino]cyclohex-2-en-1-one
• CAS NO: 51409-75-7
• Molecular Weight: 203.241
• Mol File: 51409-75-7.mol

Chemical Properties

• CAS DataBase Reference: 3-[(4-hydroxyphenyl)amino]cyclohex-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[(4-hydroxyphenyl)amino]cyclohex-2-en-1-one(51409-75-7)
• EPA Substance Registry System: 3-[(4-hydroxyphenyl)amino]cyclohex-2-en-1-one(51409-75-7)

Safety Data

• Hazardous Substances Data: 51409-75-7(Hazardous Substances Data)

Upstream product

• 123-30-8 4-amino-phenol 
• 504-02-9 1,3-cylohexanedione 

Downstream Products

• 1605319-61-6 4-(5-(1H-imidazol-1-yl)-3-methyl-1-phenyl-1H-pyrazol-4-yl)-2-amino-1-(4-hydroxyphenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide 
• 1605319-60-5 ethyl 4-(5-(1H-imidazol-1-yl)-3-methyl-1-phenyl-1H-pyrazol-4-yl)-2-amino-1-(4-hydroxyphenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate 

Relevant articles and documents

Ionic liquid promoted synthesis of β-enamino ketones at room temperature

β-Enamino ketones have been synthesised in excellent yield at room temperature in the absence of any added catalyst by the reaction of aromatic or aliphatic amines with 1,3-dicarbonyl compounds in ionic liquid. The ionic liquid is recycled and reused several times. Georg Thieme Verlag Stuttgart.

Photocyclization to cis-Hexahydrocarbazol-4-ones: Substrate Modification, Mechanism, and Scope

Upon irradiation at = 366 nm, tertiary N-alkoxycarbonyl-N-aryl-β-enaminones furnished exclusively the trans-hexahydrocarbazol-4-ones by a conrotatory [6π] photocyclization but epimerized on silica to cis-hexahydrocarbazol-4-ones (14 examples, 44-98% yield). The acceptor substitution on the nitrogen atom enhanced the stability of the cyclized products compared to N-alkyl-N-aryl-β-enaminones reported previously. The mechanism of the [6π] photocyclization was investigated by quenching experiments, deuterium-labeling experiments, and DFT calculations, suggesting a triplet pathway for the conrotatory ring closure followed by a suprafacial [1,4] hydrogen migration.

Synthesis, characterization and pharmacological screening of some novel 5-imidazopyrazole incorporated polyhydroquinoline derivatives

A new category of polyhydroquinoline derivatives 8a-t were synthesized in moderate to good yield (64-85%) by one-pot three-component cyclocondensation reaction of 5-(1H-imidazol-1-yl)-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde 3 with various enaminones