51409-84-8

Upstream product

• 126-81-8 dimedone 
• 95-51-2 o-chloroaniline 

Downstream Products

• 1154040-32-0 1-(2-chlorophenyl)-6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione 
• 1196958-00-5 9-(2-(2-chlorophenylamino)-4,4-dimethyl-6-oxocyclohex-1-enyl)-10-(2-chlorophenyl)-3,4-dihydro-3,-3-dimethylacridin-1(2H,9H,10H)-one 
• 939288-33-2 1-(2-chlorophenyl)-7,7-dimethyl-4-phenyl-3,4,7,8-tetrahydroquinoline-2,5(1H,6H)-dione 
• 1448015-44-8 5-amino-7-(2-chlorophenyl)-9,9-dimethyl-11-oxo-2,3,3a,3a¹,7,8,9,10,11,11b-decahydro-1H-pyrido[2,3,4-gh]phenanthridine-3a¹,4-dicarbonitrile 
• 1591873-31-2 C₃₅H₂₉ClN₂O₄ 

Relevant academic research and scientific papers

Catalyst-free Synthesis of Tetrahydroacenaphtho[1,2-b]indolone Derivatives via One-pot Four-component Reaction

A simple and efficient one-pot synthesis of tetrahydroacenaphtho[1,2-b]indolone derivatives via four-component reaction of 5,5-dimethylcyclohexane-1,3-dione (dimedone), arylamines, acenaphthoquinone, and active methylene compounds under catalyst-free conditions is described. The reactions were carried out under mild conditions using ethanol as solvent. Advantages of this method include simple experimental and workup procedure, readily available starting materials, and high yields.

Silica sulfuric acid-mediated synthesis of β-enaminones and β-enaminoesters under microwave irradiation

Silica sulfuric acid, a heterogeneous reagent, has been found to be an efficient catalyst for the synthesis of β-enaminones and β-enaminoesters under microwave irradiation in a microwave reactor within 2 min. The experimental procedure is simple and environment-friendly, and results in excellent yields of the products. Further, the catalyst is recyclable, and the reaction is 60 times faster than the reaction at room temperature. Copyright Taylor & Francis Group, LLC.

Molecular iodine-catalyzed mild and effective synthesis of β-enaminones at room temperature

Molecular iodine has been found to be an efficient and ecofriendly catalyst for the synthesis of β-enaminones from dimedone and amines at room temperature in the presence of acetonitrile within 60 min. The experimental procedure is simple, includes shorter reaction times, and results in excellent yields of the products. Copyright

An improved method for the synthesis of carbazolones by palladium/copper-catalyzed intramolecular annulation of n -arylenaminones

An improved method for the synthesis of carbazolones via the condensation of arylamines with 1,3-cyclodiketones followed by intramolecular oxidative cyclization catalyzed by palladium acetate and copper acetate in ethanol under an oxygen atmosphere was established. The improved method has the advantage of easily available starting materials and affords good yields.

3-Anilino-5,5-disubstituted-2-aminomethyl-2-cyclohexen-1-ones and the salts thereof

Novel cyclohexenone derivatives, which are shown by the general formula SPC1 Wherein each of R1 and R2 represents a hydrogen atom, lower alkyl or phenyl group; one of R3 and R4 represents a hydrogen atom or lower alkyl group, and the other represents an unsubstituted or substituted phenyl, lower alkyl or aralkyl group, or R3 and R4, taken together with the adjacent nitrogen atom, form a 5 to 6-membered heterocyclic ring; one of R5 and R6 represents a hydrogen atom or lower alkyl group, and the other represents a lower alkyl, phenyl or aralkyl group, or R5 and R6, taken together with the adjacent nitrogen atom, form an unsubstituted or substituted 5 to 6-membered heterocyclic ring, and their pharmaceutically acceptable salts, useful medicines such as analgesics.