51415-75-9Relevant academic research and scientific papers
Process for making a 2'-halopenicillin
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, (2008/06/13)
A 2'-halopenicillin compound is prepared from a penicillin-1-oxide compound by the action of an acid halide in the presence of a base. The product on heating rearranges to a 3-halo-3-methylcepham compound which itself gives a 3-methyl-3-cephem compound on
3-Halo-cepham derivatives
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, (2008/06/13)
Penicillin sulfoxides are converted to 3-halo-3-methyl-cepham-4-carboxylic acid esters and amides or the corresponding cephem derivatives by heating the penicillin sulfoxide precursor in a polyhaloalkane solvent to a temperature between 50° to about 150°C
