51417-52-8

Usage

Uses

Used in Pharmaceutical Synthesis:
2,4-dichlorobenzoic anhydride is utilized as a key intermediate in the synthesis of pharmaceuticals. Its role is pivotal for creating new carbon-carbon bonds, which is essential in developing a range of medicinal compounds.
Used in Organic Compound Synthesis:
Beyond pharmaceuticals, 2,4-dichlorobenzoic anhydride is also employed in the synthesis of other organic compounds. Its reactivity as an acylating agent allows for the formation of complex organic structures that are crucial in various chemical and industrial applications.
Used in Chemical Research:
In the realm of chemical research, 2,4-dichlorobenzoic anhydride serves as a valuable tool for studying the formation and properties of carbon-carbon bonds. Its reactivity provides insights into the mechanisms of bond formation and the characteristics of the resulting compounds.

Upstream product

• 50-84-0 2,4 dichlorobenzoic acid 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 89-75-8 2,4-dichlorobenzoyl chloride 

Downstream Products

• 102202-78-8 N-(2,4-dichlorobenzoyl)-2-pyrrolidone 
• 53644-53-4 3-(2,2-dichloro-1,1-difluoro-ethyl)-5-(2,4-dichloro-phenyl)-[1,2,4]oxadiazole 

Relevant academic research and scientific papers

Visible light-induced transformation of aldehydes to esters, carboxylic anhydrides and amides

A transition metal- and organophotocatalyst free synthesis of esters, carboxylic anhydrides and amides from aldehydes induced by visible-light has been reported. The proposed methodology can be carried out by the use of sunlight or artificial visible light as a blue LED source. The methodology has a very broad applicability and the desired products are obtained in very satisfactory yields.

In vitro optimization of non-small cell lung cancer activity with troxacitabine, L-1,3-dioxolane-cytidine, prodrugs

L-1,3-Dioxolane-cytidine, a potent anticancer agent against leukemia, has limited efficacy against solid tumors, perhaps due to its hydrophilicity. Herein, a library of prodrugs were synthesized to optimize in vitro antitumor activity against non-small cell lung cancer. N4-Substituted fatty acid amide prodrugs of 10-16 carbon chain length demonstrated significantly improved antitumor activity over L-1,3-dioxolane-cytidine. These in vitro results suggest that the in vivo therapeutic efficacy of L-1,3-dioxolane- cytidine against solid tumors may be improved with prodrug strategies.

ZnCl2-mediated synthesis of carboxylic anhydrides using 2-acyl-4,5-dichloropyridazin-3(2H)-ones

ZnCl2 is an efficient catalyst for synthesis of carboxylic acid anhydride from 2-acyl-4,5-dichloropyridazin-3(2H)-ones. Treatment of 2-acyl-4,5-dichloropyridazin-3(2H)-ones with ZnCl2 (0.5 equivalents) and air in refluxing dry THF or