51419-40-0

Usage

Uses

Used in Pharmaceutical Industry:
N-(5-Nitro-thiophene-2-yl)-acetamide is used as a key intermediate in the synthesis of pharmaceuticals for its antimicrobial and anti-inflammatory properties. It aids in the development of new drugs that can combat various infections and inflammations.
Used in Agrochemical Industry:
In the agrochemical sector, N-(5-Nitro-thiophene-2-yl)-acetamide is utilized as a component in the formulation of pesticides and other agrochemicals, leveraging its antimicrobial properties to protect crops and enhance agricultural productivity.
Used in Organic Synthesis:
N-(5-Nitro-thiophene-2-yl)-acetamide is used as a versatile building block in organic synthesis, particularly for the production of heterocyclic compounds. Its unique structure allows it to be a valuable intermediate in various chemical processes, contributing to the creation of a wide range of chemical products.

Upstream product

• 13053-81-1 2-acetylaminothiophene 
• 108-24-7 acetic anhydride 
• 79023-57-7 5-nitro-2-aminothiophene 

Downstream Products

• 77471-70-6 N-acetyl, N-ethoxycarbonylmethyl 2-amino, 5-nitrothiophen 
• 79023-57-7 5-nitro-2-aminothiophene 

Relevant academic research and scientific papers

MODIFIED PROTEINS AND PROTEIN DEGRADERS

Provided herein are compounds, pharmaceutical compositions, and methods for binding or degrading target proteins. Further provided herein are compounds having a DNA damage-binding protein 1 (DDB1) binding moiety. Some such embodiments include a linker. Some such embodiments include a target protein binding moiety. Further provided herein are ligand-DDB1 complexes. Further provided herein are in vivo modified DDB1 proteins.

The synthesis of highly active thiophene ring-containing chromophore components for photonic polymers based on a newly designed route

2-Aminothiophene derivatives are the key intermediates for the present synthesis. It is known that the synthesis of 2-aminothiophene is troublesome although it is a rather simple heterocycle. In this work, an early report was newly developed as a basis for the efficient synthesis of thiophene-ring-containing chromophore components for photonic polymers. 2-Amino-5-nitrothiophene and 2-amino-3,5-dinitrothiophene were synthesized in excellent yield. After diazotization, the 2-aminothiophene derivatives were directly treated with N-phenyldiethanolamine to afford two-electron push-pull compounds. A similar styryl compound was also prepared. All of these chromophore molecules have further polymerizable hydroxy groups on one end of the molecule. These compounds are currently showing interesting potential in making highly sensitive, nonlinear optical polymeric materials. The Royal Society of Chemistry 1999.

Functional Derivatives of Thiophene. I. Synthesis and 1H-NMR Spectra in the 2-Aminothiophene Series.

The preparation of 2-amino-5-nitrothiophene, 2-formamido-5-nitrothiophene, 2-acetamido-5-nitrothiophene and 2-t-butoxycarbonylamino-5-nitrothiophene are described.Abnormal values of the coupling constants J3,4 had been observed in the 1H-NMR spectra of compounds obtained.