51420-72-5

Basic information

• Product Name: 5,7-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDIN-2-AMINE
• Synonyms: 5,7-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDIN-2-AMINE;5,7-bis(trifluoromethyl)[1,8]naphthyridin-2-ylamine;7-Amino-2,4-bis(trifluoromethyl)-1,8-naphthyridine
• CAS NO: 51420-72-5
• Molecular Formula: C₁₀H₅F₆N₃
• Molecular Weight: 281.16
• Mol File: 51420-72-5.mol
• Article Data: 10

Chemical Properties

• Melting Point: 195-197°C
• Boiling Point: 288.6°Cat760mmHg
• Flash Point: 128.4°C
• Appearance: /
• Density: 1.568g/cm³
• Vapor Pressure: 0.00231mmHg at 25°C
• Refractive Index: 1.519
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5,7-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDIN-2-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDIN-2-AMINE(51420-72-5)
• EPA Substance Registry System: 5,7-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDIN-2-AMINE(51420-72-5)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25-36
• Safety Statements: 26-45
• HazardClass: IRRITANT
• Hazardous Substances Data: 51420-72-5(Hazardous Substances Data)

Usage

General Description

5,7-Bis(trifluoromethyl)[1,8]naphthyridin-2-amine is a chemical compound with the molecular formula C14H6F6N2. It is a naphthyridine derivative that contains two trifluoromethyl groups attached to the 5 and 7 positions of the naphthyridine ring. This chemical compound is often used in the pharmaceutical industry as a building block in the synthesis of various drugs and pharmaceuticals. Its unique structure and functional groups make it a valuable intermediate for the production of new compounds with potential therapeutic applications. Additionally, the trifluoromethyl groups in this compound can make it highly resistant to metabolic degradation, making it a useful tool in drug development.

InChI:InChI=1/C10H5F6N3/c11-9(12,13)5-3-6(10(14,15)16)18-8-4(5)1-2-7(17)19-8/h1-3H,(H2,17,18,19)

Upstream product

• 141-86-6 2.6-diaminopyridine 
• 1522-22-1 1,1,1,5,5,5-hexafluoroacetylacetone 

Downstream Products

• 106582-41-6 7-chloro-2,4-di(trifluoromethyl)-1,8-naphthyridine 
• 439094-96-9 2,4-bis(trifluoromethyl)imidazo[1,2-a][1,8]naphthyridine-8-carboxylic acid 
• 691868-88-9 RO8191 
• 1402247-90-8 C₁₉H₁₃BF₈N₄O 
• 1402247-87-3 C₁₉H₁₄F₆N₄O 
• 51420-73-6 2-hydroxy-5,7-bis(trifluoromethyl)-1,8-naphthyridine 

Relevant articles and documents

IMIDAZONAPHTHYRIDINES AND IMIDAZOPYRIDOPYRIMIDINES AS IFNAR2 AGONISTS FOR TREATING SARS-COV-2 INFECTIONS

The present disclosure relates to agonists of interferon alpha and beta receptor subunit 2 (IFNAR2) for use in the treatment or prevention of viral disease, particularly COVID-19. In particular embodiments, COVID-19 is associated with pneumonia or acute respiratory distress syndrome (ARDS). In other aspects, the subject being treated is undergoing extra-corporeal membrane oxygenation, mechanical ventilation, non-invasive ventilation, receiving oxygen therapy or receiving antiviral or steroid treatment.

Fluorescent probe for marking amyloid protein as well as preparation method and application thereof

The invention belongs to the field of biomedicines, and concretely relates to amyloid protein-labeled fluorescence probes, and a making method and an application thereof. The fluorescence probes are compounds represented by formula I, and R1 and R2 in the formula I are independently selected from -CF3 and -CN. The invention also relates to the application of the compounds of formula I in amyloid protein labeling as the fluorescence probes. The compounds of formula I can be used for preparing products for diagnosing the Alzheimer's disease. BODIPY fluorescence probe molecules containing a bioactive 1,8-naphthyridyl group as a parent compound are synthesized for the first time, can be applied to beta-amyloid protein labeling, and can be used for the early stage diagnosis of the Alzheimer's disease.

COMPOUNDS AND METHODS FOR ENHANCING INNATE IMMUNE RESPONSES

Provided are certain compounds and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections.