51422-72-1

Basic information

• Product Name: 1-bromo-2-fluorocyclopentane
• Synonyms: Cyclopentane, 1-bromo-2-fluoro-, cis- (9CI)
• CAS NO: 51422-72-1
• Molecular Formula: C₅H₈BrF
• Molecular Weight: 167.0194
• Mol File: 51422-72-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 141.1°C at 760 mmHg
• Flash Point: 41°C
• Density: 1.48g/cm³
• Vapor Pressure: 7.44mmHg at 25°C
• Refractive Index: 1.463
• CAS DataBase Reference: 1-bromo-2-fluorocyclopentane(CAS DataBase Reference)
• NIST Chemistry Reference: 1-bromo-2-fluorocyclopentane(51422-72-1)
• EPA Substance Registry System: 1-bromo-2-fluorocyclopentane(51422-72-1)

Safety Data

• Hazardous Substances Data: 51422-72-1(Hazardous Substances Data)

Upstream product

• 142-29-0 cyclopentene 
• 137-43-9 Cyclopentyl bromide 

Relevant articles and documents

Synthesis of sp 3-Enriched β-Fluoro Sulfonyl Chlorides

A three-step approach to the synthesis of sp 3-enriched β-fluoro sulfonyl chlorides starting from alkenes is reported. The method was successfully applied to a wide range of acyclic and cyclic substrates, bearing either an exocyclic or an endocyclic double bond. The procedure worked with a wide range of substrates and tolerated a number of functional and protecting groups. Moreover, the target cyclic compounds were obtained as single cis diastereomers on a multigram scale. The title compounds are promising building blocks for drug discovery that can be used to obtain sp 3-enriched β-fluoro and α,β-unsaturated sulfonamides.

Unusual β-Fluorination of Secondary Alkyl and Cycloalkyl Bromides in Their Reaction with NO2+BF4- in (HF)n-Pyridine Solution

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