514225-48-0

Basic information

• Product Name: 1H-Pyrimido[1,2-a]quinoxaline, 2,3-dihydro-5-(4-nitrophenyl)-, 6-oxide
• CAS NO: 514225-48-0
• Molecular Formula: C17H14N4O3
• Molecular Weight: 322.323
• Mol File: 514225-48-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1H-Pyrimido[1,2-a]quinoxaline, 2,3-dihydro-5-(4-nitrophenyl)-, 6-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrimido[1,2-a]quinoxaline, 2,3-dihydro-5-(4-nitrophenyl)-, 6-oxide(514225-48-0)
• EPA Substance Registry System: 1H-Pyrimido[1,2-a]quinoxaline, 2,3-dihydro-5-(4-nitrophenyl)-, 6-oxide(514225-48-0)

Safety Data

• Hazardous Substances Data: 514225-48-0(Hazardous Substances Data)

Upstream product

• 50434-36-1 4-nitrophenylacetyl chloride 
• 514225-43-5 N-(p-nitrophenylacetyl)-N'-(o-nitrophenyl)-1,3-propanediamine 
• 145315-42-0 N₁-(2-nitrophenyl)propane-1,3-diamine 

Relevant articles and documents

Pyrimido[1,2-a]quinoxaline 6-oxide and phenazine 5,10-dioxide derivatives and related compounds as growth inhibitors of Trypanosoma cruzi

Two different families of N-oxide containing heterocycles were evaluated as in vitro growth inhibitors of T. cruzi. Both families of heterocycles were selected from our in-house library of compounds as analogues of active anti-T. cruzi N-oxide containing heterocycles. Derivatives from pyrimido[1,2-a]quinoxaline 6-oxide family were poorly active at the assayed doses. However, phenazine 5,10-dioxide derivatives displayed good to excellent anti-T. cruzi activities. The anti-T. cruzi activity of phenazine derivatives was related to substituent' electronic descriptors, σp-. Derivatives 19, 20 and 23 were the most cytotoxic compounds against the protozoan and became excellent hit for further structural modifications.