51440-69-8

Basic information

• Product Name: 5-tert-butylpyrazine-2,3-dicarbonitrile
• Synonyms: 5-tert-butylpyrazine-2,3-dicarbonitrile;2,3-Pyrazinedicarbonitrile, 5-(1,1-diMethylethyl)-
• CAS NO: 51440-69-8
• Molecular Formula: C10H10N4
• Molecular Weight: 186.2132
• EINECS: -0
• Mol File: 51440-69-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 344.2±42.0 °C(Predicted)
• Appearance: /
• Density: 1.15±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -6.92±0.10(Predicted)
• CAS DataBase Reference: 5-tert-butylpyrazine-2,3-dicarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-tert-butylpyrazine-2,3-dicarbonitrile(51440-69-8)
• EPA Substance Registry System: 5-tert-butylpyrazine-2,3-dicarbonitrile(51440-69-8)

Safety Data

• Hazardous Substances Data: 51440-69-8(Hazardous Substances Data)

Usage

General Description

5-tert-butylpyrazine-2,3-dicarbonitrile is a chemical compound that belongs to the class of pyrazine derivatives. It is characterized by the presence of two carbonitrile (CN) functional groups on the 2,3 positions of the pyrazine ring. The tert-butyl group at the 5-position provides steric hindrance and contributes to the compound's overall structure and reactivity. This chemical is commonly used as a building block in organic synthesis and pharmaceutical research, and its unique structure makes it a valuable intermediate for the production of various compounds. Its properties and applications make it a significant molecule in the field of organic chemistry and drug development.

Upstream product

• 4480-47-1 t-butylglyoxal 
• 18514-52-8 2,3-diaminomaleonitrile 
• 2987-16-8 3,3-dimethylbutyrylaldehyde 
• 1187-42-4 diaminomaleonitrile 
• 13481-25-9 pyrazine-2,3-dicarbonitrile 
• 75-98-9 Trimethylacetic acid 
• 13401-18-8 1,3-Dimethyllumazine 

Relevant articles and documents

Synthesis of a tetrapyrazinoporphyrazine-based fluorescent sensor for detection of Cu2+ ion

In this study, a novel tetrapyrazinoporphyrazine-based fluorescent sensor for Cu2+ ion was synthesized and fully characterized by 1H NMR, MALDI-TOF MS, and elemental analysis. A tetrapyrazinoporphyrazine substituent was used as the reporting group and a 2,2′-dipyridylamine moiety was employed as the recognition group. The effects of various metal ions on the absorption and emission spectra of the designed molecule were investigated, demonstrating that this compound shows selectivity and sensitivity toward the Cu2+ ion. Upon addition of Cu2+ ion, a fluorescent intensity of the tetrapyrazinoporphyrazine-based sensor decreased gradually at 655?nm. To confirm a selective binding ability of 2,2′-dipyridylamine moiety toward Cu2+ ion, a comparative study was performed using tetrapyrazinoporphyrazine derivative with bromine instead of 2,2′-dipyridylamine moiety. Furthermore, association constant and detection limit value of the synthesized compound toward Cu2+ ion were derived from a repetitive titration experiment. Also, a reversibility of the prepared sensor was confirmed through additional test using compound and ethylenediaminetetraacetic acid.

Reaction of Pyrazine-2,3-dicarbonitrile and 1,3-Dimethyllumazine with Alkyl Radicals

Pyrazine-2,3-dicarbonitrile (1) reacts with alkyl radicals to give mono- 3 and di-alkylated pyrazine-2,3-dicarbonitriles 4.Similarly 1,3-dimethyllumazine (2) reacts with alkyl radicals to give 7-alkyl-1,3-dimethyllumazines 8 as a major product.The reactivity of alkyl radicals decreases in the order tertiary, secondary, and primary, and 1 is more reactive than 2 in those radical substitution reactions.