51458-01-6Relevant academic research and scientific papers
N-substituted hydroxyureas as urease inhibitors
Uesato, Shinichi,Hashimoto, Yuichiro,Nishino, Masaru,Nagaoka, Yasuo,Kuwajima, Hiroshi
, p. 1280 - 1282 (2002)
In order to seek a urease inhibitor more potent than hydroxyurea (1), its alkyl- or phenyl-substituted derivatives were synthesized and evaluated for their effect on the jack bean urease. Of 16 compounds tested, m-methyl-(10) and m-methoxy-phenyl substituted hydroxyurea (13) showed the most potent inhibitory activities against the enzyme.
Synthesis and SAR of 1-hydroxy-1 H -benzo[ d ]imidazol-2(3 H)-ones as inhibitors of d -amino acid oxidase
Berry, James F.,Rais, Rana,Slusher, Barbara S.,Tsukamoto, Takashi,Ferraris, Dana V.,Duvall, Bridget,Hin, Niyada,Alt, Jesse,Thomas, Ajit G.,Rojas, Camilo,Hashimoto, Kenji
supporting information, p. 839 - 843,5 (2020/09/15)
A series of 1-hydroxy-1H-benzo[d]imidazol-2(3H)-ones were synthesized and evaluated for their ability to inhibit human and porcine forms of d-amino acid oxidase (DAAO). The inhibitory potency is largely dependent on the size and position of substituents o
