51478-46-7

Upstream product

• 5649-38-7 (2-amino-6-chlorophenyl)phenylmethanone 
• 140-29-4 phenylacetonitrile 
• 25108-32-1 1-(4-chlorophenyl)-1H-1,2,3,4-tetrazole 
• 501-65-5 diphenyl acetylene 

Downstream Products

• 1269612-26-1 N₄,N₆-bis(6-chloro-3,4-diphenylquinolin-2-yl)-2-isopropylpyrimidine-4,6-diamine 

Relevant academic research and scientific papers

Preparing multi-substituted quinoline type larene and method of pyridine derivatives (by machine translation)

The invention discloses a preparing a multi-substituted quinoline type larene and pyridine derivatives. The method comprises the following steps: in the formula II the phenyl tetrazole compounds, alkine compound shown in formula III, alkali, oxidant and catalyst mix, cyclized-denitrification in series of the reaction, the reaction of the compound of the formula I obtained shows. The method has the following characteristics : (1) the economic ; (2) convenient; reaction only needs one-step, one-time feeding and a secondary separation step of the final product can be obtained, because the reaction has a very high chemical selectivity, the separation process is very simple. (3) general ; (4) green. The obtained product is a reaction intermediate in the discharged nitrogen, no other exhaust gas discharge, no pollution to the environment. More importantly, the reaction by-product of aniline nitrogen nitrile base can be used as a new chemical raw materials in other reaction. A high utilization rate of atom of the reaction, no pollution to the environment. (by machine translation)

One-pot synthesis of multisubstituted 2-aminoquinolines from annulation of 1-aryl tetrazoles with internal alkynes via double C-H activation and denitrogenation

An efficient, one-pot synthesis of multisubstituted 2-aminoquinolines from 1-aryl tetrazoles and internal alkynes has been developed. The reaction involves cyclization of 1-aryl tetrazoles with internal alkynes via rhodium(III)-catalyzed double C-H activa

Synthesis of diheteroarylamine ligands by palladium-catalyzed mono- and diamination of dichloroheteroarenes with heteroarenamines

The syntheses of bidentate (see 6 and 12), bis-bidentate (7, 10, and 13) up to oligo-bidentate (see 11 and 14) diheteroarylamine-based N,N-ligands are reported (Tables 2, 4, and 5). In the course of investigations on heteroaromatic (C-N)-bond formations,