514797-26-3

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 514797-24-1 ethyl (E)-3-[(2-tert-butyldimethylsilyloxy)phenyl]prop-2-enoate 
• 3943-94-0 (E)-ethyl 2-hydroxycinnamate 
• 514797-25-2 (E)-3-(2-((tert-butyldimethylsilyl)oxy)phenyl)prop-2-en-1-ol 
• 60125-23-7 (E)-3-(2-hydroxyphenyl)propenal 

Downstream Products

• 514797-29-6 (E)-3-[(2-tert-butyldimethylsilyloxy)phenyl]-1-phenylprop-2-enol 
• 514797-27-4 acetic acid (E)-3-[(2-tert-butyldimethylsilyloxy)phenyl]-1-phenylprop-2-enol ester 
• 514797-28-5 acetic acid (E)-3-(2-hydroxyphenyl)-1-phenylprop-2-enol ester 
• 93514-42-2 2-phenylchromene 

Relevant academic research and scientific papers

Palladium(0)-catalyzed synthesis of 2-phenyl-2H-chromene

2-Phenyl-2H-chromene is obtained in quite good yield starting from 3-[(2-tert-butyldimethylsilyl)oxyphenyl]prop-2-enal. Condensation of this aldehyde with phenyl magnesium bromide, followed by the acetylation of the alcohol obtained, and then intramolecular cyclization in the presence of a palladium catalyst gave the phenylchromene in an overall 34% yield.