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51481-60-8

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51481-60-8 Usage

Chemical Properties

White or almost white, hygroscopic, crystalline powder.

Uses

Naloxone Hydrochloride Dihydrate is a specific opioid antagonist. Narcotic antagonist.

Biochem/physiol Actions

Competitive antagonist for μ, κ, δ, and σ opioid receptors; blocks the action of σ-agonists at opioid sites. Naloxone′s antagonistic effect last for about 45 min and thus, requires repeated dosage. It results in critical side effects such as pulmonary edema.

Purification Methods

This opiate antagonist has been recrystallised from EtOH/Et2O or H2O. It is soluble in H2O (5%) and EtOH but insoluble in Et2O. The free base has m 184o (177-178o also reported) after recrystallisation from EtOAc, and [] D -194.5o (c 0.93, CHCl3). [Olofson et al. Tetrahedron Lett 1567 1977, Gold et al. Med Res Rev 2 211 1982.]

Check Digit Verification of cas no

The CAS Registry Mumber 51481-60-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,4,8 and 1 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 51481-60:
(7*5)+(6*1)+(5*4)+(4*8)+(3*1)+(2*6)+(1*0)=108
108 % 10 = 8
So 51481-60-8 is a valid CAS Registry Number.
InChI:InChI=1/C19H21NO4.ClH.2H2O/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;;;/h2-4,14,17,21,23H,1,5-10H2;1H;2*1H2/t14-,17+,18+,19-;;;/m1.../s1

51481-60-8Upstream product

51481-60-8Downstream Products