514830-29-6

Upstream product

• 100-10-7 4-dimethylamino-benzaldehyde 
• 514830-23-0 acetic acid N'-[3-(2-chloro-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-hydrazide 
• 340-57-8 mecloqualone 
• 514830-19-4 3-(2-chloro-phenyl)-2-hydrazinomethyl-3H-quinazolin-4-one 
• 61554-50-5 2-Bromomethyl-3-(2-chloro-phenyl)-3H-quinazolin-4-one 

Relevant academic research and scientific papers

Synthesis and anti-inflammatory activity of some new 2,3-disubstituted-6-monosubstituted-quinazolin-4(3H)-ones

Some new quinazolinone derivatives, 3-(substituted phenyl)-2-(substituted phenylchalconylaminoazetidinon-2′-yl)-6-monosubstitutedquinazolin-4 (3H)-ones have been synthesized by the reaction of 3-(substituted phenyl)-2-(substituted phenylchalconylhydrazinomethyl)-6-monosubstituted-quinazolin-4(3H)-ones with acetyl chloride in the presence of triethylamine. All the compounds of this series have been evaluated for their anti-inflammatory activity against carrageenan induced oedema in albino rats. The activity of the most active member of this series i.e. 3-(o-methoxyphenyl)-2-(p-dimethylaminophenylchalconylaminoazetidinon- 2′-yl) quinazolin-4(3H)-one has been studied in detial and is compared with phenylbutazone. Interestingly this compound exhibits better anti-inflammatory activity and lower ulccrogenic liability than phenylbutazone and its toxicity is also quite low.