51484-09-4

Basic information

• Product Name: (3R)-3,4-Dihydro-6,8-dihydroxy-3-[[(2R,6S)-tetrahydro-4-hydroxy-6-methyl-2H-pyran-2-yl]methyl]-1H-2-benzopyran-1-one
• Synonyms: (3R)-3,4-Dihydro-6,8-dihydroxy-3-[[(2R,6S)-tetrahydro-4-hydroxy-6-methyl-2H-pyran-2-yl]methyl]-1H-2-benzopyran-1-one;4'-Hydroxyasperentin
• CAS NO: 51484-09-4
• Molecular Formula: C16H20O6
• Molecular Weight: 308.33
• Mol File: 51484-09-4.mol

Chemical Properties

• Boiling Point: 611.6°C at 760 mmHg
• Flash Point: 229.8°C
• Appearance: /
• Density: 1.347g/cm³
• Vapor Pressure: 8.16E-16mmHg at 25°C
• Refractive Index: 1.593
• PKA: 8.09±0.40(Predicted)
• CAS DataBase Reference: (3R)-3,4-Dihydro-6,8-dihydroxy-3-[[(2R,6S)-tetrahydro-4-hydroxy-6-methyl-2H-pyran-2-yl]methyl]-1H-2-benzopyran-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3R)-3,4-Dihydro-6,8-dihydroxy-3-[[(2R,6S)-tetrahydro-4-hydroxy-6-methyl-2H-pyran-2-yl]methyl]-1H-2-benzopyran-1-one(51484-09-4)
• EPA Substance Registry System: (3R)-3,4-Dihydro-6,8-dihydroxy-3-[[(2R,6S)-tetrahydro-4-hydroxy-6-methyl-2H-pyran-2-yl]methyl]-1H-2-benzopyran-1-one(51484-09-4)

Safety Data

• Hazardous Substances Data: 51484-09-4(Hazardous Substances Data)

Usage

Uses

Used in Health and Nutrition Industry:
(+)-Catechin is used as a dietary supplement for its antioxidant properties, helping to combat oxidative stress and support overall health. It is particularly valued for its potential to reduce the risk of heart disease, improve cholesterol levels, and support immune and brain health.
Used in Pharmaceutical Research:
(+)-Catechin is utilized in pharmaceutical research for its potential therapeutic applications. Its antioxidant and health-promoting properties make it a candidate for the development of treatments targeting various diseases and conditions, with a focus on cardiovascular health and cognitive function.
Used in Functional Food and Beverage Development:
(+)-Catechin is incorporated into functional foods and beverages to enhance their health benefits. Its presence can contribute to the product's antioxidant content, potentially offering consumers added protection against free radicals and supporting a range of health benefits.
Used in Cosmetics and Skincare:
(+)-Catechin is also used in cosmetics and skincare products for its antioxidant properties. It can help protect the skin from environmental damage, promote collagen production, and support skin health and appearance.

InChI:InChI=1/C16H20O6/c1-8-2-10(17)5-13(21-8)7-12-4-9-3-11(18)6-14(19)15(9)16(20)22-12/h3,6,8,10,12-13,17-19H,2,4-5,7H2,1H3

Upstream product

• 35818-31-6 cladosporin 

Relevant articles and documents

Cladosporin Derivatives Obtained by Biotransformation Provide Guidance for the Focused Derivatization of this Antimalarial Lead Compound

Cladosporin, a natural product known for decades, has recently been discovered to display potent and selective antiplasmodial activity by inhibition of lysyl-tRNA synthetase. It was subjected to a panel of oxidative biotransformations with one fungal and two actinomycetes strains, as well as a triple mutant bacterial CYP102A1, yielding eight, mostly hydroxylated, derivatives. These new compounds covered a wide chemical space and contained two pairs of epimers in the tetrahydropyran ring. Although less potent than the parent compound, all analogues showed activity in a cell-based synthetase assay, thus demonstrating uptake and on-target activity in living cells with varying degrees of selectivity for the enzyme lysyl-tRNA synthetase from Plasmodium falciparum and highlighting sites suitable for synthesis of future cladosporin analogues. Compounds with adjacent hydroxy functions showed different MS/MS fragmentation that can be explained in terms of an, in some cases, regioselective loss of water followed by a retro-Diels–Alder reaction.