514842-83-2Relevant academic research and scientific papers
Selective addition of amines to 5-trifluoromethyl-2,4-dichloropyrimidine induced by Lewis acids
Richter, Daniel T.,Kath, John C.,Luzzio, Michael J.,Keene, Nandell,Berliner, Martin A.,Wessel, Matthew D.
supporting information, p. 4610 - 4612 (2013/08/23)
A variety of 2,4-diamino-pyrimidine systems can be prepared from the corresponding 2,4-dichloro-pyrimidine by sequential addition of two amines, the first adding selectively to the 4-position. In contrast it was found that 2,4-dichloro-5-trifluoromethyl-p
SELECTIVE SYNTHESIS OF CF3-SUBSTITUTED PYRIMIDINES
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Page/Page column 11, (2008/06/13)
The present invention relates to a method of making a compound of the formula (I),wherein X1, X2 and R3-R4 are as defined herein. The method includes reacting a compound of the formula (II) with an amine of formula (III) (HNR33R44) in the presence of a Lewis Acid and a non-nucleophilic base. The 2,4-diamino pyrimidine moiety is a common component in a variety of biologically active drug-like molecules and pyrimidine derivatives have been found to be useful in the 10 treatment of abnormal cell growth, such as cancer, in mammals.
Pyrimidine derivatives
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, (2011/04/19)
The present invention relates to trisubstituted pyrimidines of formula (I) 1wherein 0Ra to Re are defined as in claim 1, which are suitable for the treatment of illnesses characterised by excessive or abnormal cell proliferation, the use thereof for preparing a pharmaceutical composition with the abovementioned properties, and processes for the preparation thereof.
