514844-43-0Relevant academic research and scientific papers
New active series of growth hormone secretagogues
Guerlavais, Vincent,Boeglin, Damien,Mousseaux, Delphine,Oiry, Catherine,Heitz, Annie,Deghenghi, Romano,Locatelli, Vittorio,Torsello, Antonio,Ghé, Corrado,Catapano, Filomena,Muccioli, Giampiero,Galleyrand, Jean-Claude,Fehrentz, Jean-Alain,Martinez, Jean
, p. 1191 - 1203 (2003)
New growth hormone secretagogue (GHS) analogues were synthesized and evaluated for growth hormone releasing activity. This series derived from EP-51389 is based on a gem-diamino structure. Compounds that exhibited higher in vivo GH-releasing potency than hexarelin in rat (subcutaneous administration) were then tested per os in beagle dogs and for their binding affinity to human pituitary GHS receptors and to hGHS-R 1a. Compound 7 (JMV 1843, H-Aib-(D)-Trp-(D)-gTrp-formyl) showed high potency in these tests and was selected for clinical studies.
