514845-17-1Relevant academic research and scientific papers
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 3: Polar functionality and its effect on anti-HIV-1 activity
Hale, Jeffrey J.,Budhu, Richard J.,Mills, Sander G.,MacCoss, Malcolm,Gould, Sandra L.,DeMartino, Julie A.,Springer, Martin S.,Siciliano, Salvatore J.,Malkowitz, Lorraine,Schleif, William A.,Hazuda, Daria,Miller, Michael,Kessler, Joseph,Danzeisen, Renee,Holmes, Karen,Lineberger, Janet,Carella, Anthony,Carver, Gwen,Emini, Emilio A.
, p. 2997 - 3000 (2002)
Incorporation of acidic functional groups into a lead CCR5 antagonist identified from a targeted combinatorial library resulted in compounds with enhanced anti-HIV-1 activity and attenuated L-type calcium channel affinity.
