51486-03-4

Basic information

• Product Name: 2-AMINO-5-METHYL-3-THIOPHENECARBOXAMIDE
• Synonyms: 2-AMINO-5-METHYLTHIOPHENE-3-CARBOXAMIDE;2-AMINO-5-METHYL-3-THIOPHENECARBOXAMIDE;AKOS MSC-0460;3-Thiophenecarboxamide, 2-amino-5-methyl-;2-AMino-5-Methyl-thiophene-3-carboxylic acid aMide;2-AMino-5-Methyl-3-thiophenecarboxaMid
• CAS NO: 51486-03-4
• Molecular Formula: C₆H₈N₂OS
• Molecular Weight: 156.21
• Mol File: 51486-03-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 274℃
• Flash Point: 120℃
• Appearance: /
• Density: 1.344
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-AMINO-5-METHYL-3-THIOPHENECARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-METHYL-3-THIOPHENECARBOXAMIDE(51486-03-4)
• EPA Substance Registry System: 2-AMINO-5-METHYL-3-THIOPHENECARBOXAMIDE(51486-03-4)

Safety Data

• RIDADR: UN 2811 6.1 / PGIII
• Hazardous Substances Data: 51486-03-4(Hazardous Substances Data)

Usage

General Description

2-AMINO-5-METHYL-3-THIOPHENECARBOXAMIDE is a chemical compound with the molecular formula C6H8N2OS. It is a derivative of thiophene and contains an amino group and a methyl group on the thiophene ring. 2-AMINO-5-METHYL-3-THIOPHENECARBOXAMIDE is commonly used in organic synthesis and medicinal chemistry as a building block for the synthesis of various pharmaceuticals and biologically active molecules. It has also been studied for its potential therapeutic applications in the treatment of various diseases, including cancer and neurological disorders. Additionally, 2-AMINO-5-METHYL-3-THIOPHENECARBOXAMIDE has been shown to possess antioxidant and anti-inflammatory properties, making it a potentially valuable compound for the development of new drugs and treatments.

Upstream product

• 123-38-6 propionaldehyde 
• 107-91-5 cyanoacetic acid amide 
• 138564-58-6 2-amino-5-methylthiophene-3-carbonitrile 
• 123-72-8 butyraldehyde 

Downstream Products

• 1362709-92-9 (4-fluorophenyl)(6-methyl-4-(5-methyl-1H-pyrazol-3-ylamino)thieno[2,3-d]pyrimidin-2-yl)methanol 
• 1362710-67-5 (4-chloro-6-methylthieno[2,3-d]pyrimidin-2-yl)(4-fluorophenyl)methanone 
• 1362710-69-7 (4-fluorophenyl)(6-methyl-4-(5-methyl-1H-pyrazol-3-ylamino)thieno[2,3-d]pyrimidin-2-yl)methanone 
• 79927-75-6 2,6-dimethyl-thieno[2,3-d]pyrimidin-4-one 

Relevant articles and documents

Synthesis and cytotoxic activity of chalcone analogues containing a thieno[2,3-d]pyrimidin-2-yl group as the A-ring or B-ring

Many natural or synthetic chalcones have potential anti-tumor activity. Here, we synthesized two series of chalcone analogues containing a thieno[2,3-d]pyrimidin-2-yl group and evaluated for their cytotoxic activity towards cultured human lung cancer A549 and colorectal HCT-116 cells. Among them, compound 8d was the most cytotoxic against HCT-116 cells, with an IC50 value of 2.65 μM. Analyses of the phenotypic changes induced by this compound found a dose-dependent accumulation of HCT-116 cells in sub-G1 phase, indicating that compound 8d might induce apoptosis. Furthermore, we found that 8d triggered mitochondrial membrane potential depolarization, promoted reactive oxygen species formation in HCT-116 cells, and increased the percentage of early and late apoptotic cells. Finally, immunoblotting indicated that 8d increased PARP-1 and caspases 3, 7 and 9 cleavage. These data suggest that compound 8d induces apoptosis via the mitochondrial death pathway.

THIENOPYRIDINE AND THIENOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are thienopyridine and thienopyrimidine compounds of formula (I) for treatment of JAK kinase mediated diseases, including JAK2 kinase-, JAK3 kinase- or TYK2 kinase-mediated diseases. Also provided are pharmaceutical compositions comprising

NOVEL HERBICIDES, USAGE THEREOF, NOVEL THIENOPYRIMIDINE DERIVATIVES, INTERMEDIATES OF THE SAME, AND PROCESS FOR PRODUCTION THEREOF

A herbicide comprising, as an active ingredient, a substituted thienopyrimidine derivative represented by the formula (I): wherein all symbols are defined in the description, a method of using the same, a novel compound useful as the herbicide and a process for producing the same, and an intermediate thereof.