51501-53-2

Usage

Uses

Used in Pharmaceutical Industry:
4,5,6-trichloropyrimidin-2-amine is used as a key intermediate in the synthesis of various pharmaceuticals due to its potent biological activity, contributing to the development of new drugs with diverse therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 4,5,6-trichloropyrimidin-2-amine is utilized as a building block for the production of herbicides and other crop protection agents, enhancing their effectiveness in controlling weeds and pests while ensuring crop yield and quality.
Used in Environmental Regulation:
4,5,6-trichloropyrimidin-2-amine is subject to careful usage and disposal guidelines to prevent its environmental persistence and toxicity. This involves the development and implementation of regulatory measures to minimize its negative impacts on health and the environment, ensuring sustainable chemical management practices.

InChI:InChI=1/C4H2Cl3N3/c5-1-2(6)9-4(8)10-3(1)7/h(H2,8,9,10)

Upstream product

• 4425-67-6 2-aminopyrimidine-4,6-diol 
• 1195949-91-7 4,5,6-trichloro-2-{[(dimethylamino)methylidene]amino}pyrimidine 
• 1195949-92-8 2-acetylamino-6-chloro-5-nitro-4(3H)-pyrimidinone 
• 3724-43-4 Vilsmeier reagent 
• 80466-56-4 2-amino-6-hydroxy-5-nitropyrimidin-4(3H)-one 
• 56-05-3 2-Amino-4,6-dichloropyrimidine 

Relevant academic research and scientific papers

PREPARATION AND USES OF PYRIMIDINONE DERIVATIVES

The present invention relates to compounds of formula (I), and salts and solvates thereof, that function as inhibitors of cell division cycle 7 (Cdc7) kinase enzyme activity: (Formula (I)) wherein X, R1, R2, and n are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which Cdc7 kinase activity is implicated.

PYRIMIDINONE DERIVATIVES AS CDC7 INHIBITORS

The present invention relates to compounds of formula I as defined herein, and salts and solvates thereof, that function as inhibitors of cell division cycle 7 (Cdc7) kinase enzyme activity Formula (I). The present invention also relates to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which Cdc7 kinase activity is implicated.

Syntheses of 2-amino-4,6-dichloro-5-nitropyrimidine and 2-amino-4,5,6-trichloropyrimidine: an unusual aromatic substitution

2-Amino-4,6-dichloro-5-nitropyrimidine is an intermediate required for the preparation of nitropyrimidines as inactivators of the DNA repairing protein MGMT. When attempting its synthesis, 2-amino-4,5,6-trichloropyrimidine is obtained instead, via unusual aromatic substitution of the nitro group in 2-amino-4-hydroxy-5-nitropyrimidin-6-one by chloride. The synthesis, the reactivity of 4,5,6-trichloropyrimidine and the efficient preparation of 2-amino-4,6-dichloro-5-nitropyrimidine are presented.