515135-46-3Relevant academic research and scientific papers
Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity
Angell, Richard,Aston, Nicola M.,Bamborough, Paul,Buckton, Jacky B.,Cockerill, Stuart,deBoeck, Suzanne J.,Edwards, Chris D.,Holmes, Duncan S.,Jones, Katherine L.,Laine, Dramane I.,Patel, Shila,Smee, Penny A.,Smith, Kathryn J.,Somers, Don O.,Walker, Ann L.
, p. 4428 - 4432 (2008)
The biphenyl amides (BPAs) are a novel series of p38α MAP kinase inhibitor. The optimisation of the series to give compounds that are potent in an in vivo disease model is discussed. SAR is presented and rationalised with reference to the crystallographic binding mode.
HETEROARYL SUBSTITUTED BIPHENYL DERIVATIVES AS P38 KINASE INHIBITORS
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Page/Page column 35, (2010/02/07)
Compounds of formula (I) are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38.
