515138-46-2

Upstream product

• 1005784-03-1 4-chloromethyl-2-(2,4-dichlorophenyl)-5-isopropyloxazole 
• 515138-44-0 6-acetamido-3-[2-[2-(2,4-dichlorophenyl)-5-isopropyl-4-oxazolyl]ethyl]-5-methyl-1,2-benzisoxazole 
• 515138-49-5 6-acetamido-3,5-dimethyl-1,2-benzisoxazole 
• 515138-45-1 6-amino-3-[2-[2-(2,4-dichlorophenyl)-5-isopropyl-4-oxazolyl]ethyl]-5-methyl-1,2-benzisoxazole 

Relevant academic research and scientific papers

Biological evaluation of novel benzisoxazole derivatives as PPARδ agonists

We discovered novel peroxisome proliferator-activated receptor δ agonists with a characteristic benzisoxazole ring. Compound 5 exhibited potent human PPARδ transactivation activity. Furthermore, it stimulated the differentiation of oligodendrocyte precurs

Synthesis of a novel human PPARδ selective agonist and its stimulatory effect on oligodendrocyte differentiation

We successfully synthesized a novel peroxisome proliferator-activated receptor (PPAR)δ selective agonist, namely, compound 20, with a characteristic benzisoxazole ring. Compound 20 exhibited potent human PPARδ transactivation activity and high δ selectivity. Further, it stimulated differentiation of primary oligodendrocyte precursor cells in vitro, indicating that it may be an effective drug in the treatment of demyelinating disorders such as multiple sclerosis.

ACTIVATOR FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA

A compound represented by the formula (I) or a salt of the compound, and a PPAR-δ activator which contains the compound or salt as the active ingredient: ???(wherein A represents O or S; B1 represents N, etc.; B2 represents O, etc.;