515153-75-0Relevant academic research and scientific papers
Palladium-Catalyzed Aerobic Oxidative Carbonylation of Amines Enables the Synthesis of Unsymmetrical N,N′-Disubstituted Ureas
Zeng, Honglan,Du, Hongyan,Gong, Xu,Zhang, Jie,Han, Wei
, p. 1223 - 1226 (2021/06/02)
A ligand-free palladium-catalyzed aerobic oxidative carbonylation of amines for the synthesis of ureas, particular unsymmetrically N,N′-disubstituted ureas, which cannot be accessed by any other palladium-catalyzed oxidative carbonylation of amines to date, is presented. An array of symmetrical and unsymmetrical ureas were straightforwardly synthesized by using inexpensive, readily available, stable, and safe amines with good to excellent yields under a pressure of 1 atm. This novel method employs oxygen as the sole oxidant and offers an attractive alternative to transition-metal-based oxidant systems.
Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors
Murray, Christopher W.,Berdini, Valerio,Buck, Ildiko M.,Carr, Maria E.,Cleasby, Anne,Coyle, Joseph E.,Curry, Jayne E.,Day, James E. H.,Day, Phillip J.,Hearn, Keisha,Iqbal, Aman,Lee, Lydia Y. W.,Martins, Vanessa,Mortenson, Paul N.,Munck, Joanne M.,Page, Lee W.,Patel, Sahil,Roomans, Susan,Smith, Kirsten,Tamanini, Emiliano,Saxty, Gordon
supporting information, p. 798 - 803 (2015/07/15)
The DDR1 and DDR2 receptor tyrosine kinases are activated by extracellular collagen and have been implicated in a number of human diseases including cancer. We performed a fragment-based screen against DDR1 and identified fragments that bound either at th
