515160-72-2

Basic information

• Product Name: 1-[4-(2-METHOXY-ETHOXY)-PHENYL]-PIPERAZINE
• Synonyms: 1-[4-(2-METHOXY-ETHOXY)-PHENYL]-PIPERAZINE;Piperazine, 1-[4-(2-Methoxyethoxy)phenyl]-;1-[4-(2-METHOXY-ETHOXY)-PHENYL]-PIPERAZINE hydrochloride
• CAS NO: 515160-72-2
• Molecular Formula: C₁₃H₂₀N₂O₂
• Molecular Weight: 236.31
• Mol File: 515160-72-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 383.249°C at 760 mmHg
• Flash Point: 185.583°C
• Appearance: /
• Density: 1.069g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.523
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 9.00±0.10(Predicted)
• CAS DataBase Reference: 1-[4-(2-METHOXY-ETHOXY)-PHENYL]-PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(2-METHOXY-ETHOXY)-PHENYL]-PIPERAZINE(515160-72-2)
• EPA Substance Registry System: 1-[4-(2-METHOXY-ETHOXY)-PHENYL]-PIPERAZINE(515160-72-2)

Safety Data

• Hazardous Substances Data: 515160-72-2(Hazardous Substances Data)

Usage

General Description

1-[4-(2-Methoxy-ethoxy)-phenyl]-piperazine, also known as TFMPP, is a chemical compound with psychoactive properties. It is commonly used as a recreational drug and is known to produce effects such as heightened sensory perception, altered sense of time, and hallucinations. TFMPP is a serotonin receptor agonist, specifically targeting the 5-HT2 receptor, which is involved in the regulation of mood, perception, and cognition. Due to its psychoactive effects, TFMPP is considered a controlled substance in many countries and is illegal to possess and distribute without proper authorization. It is often used in combination with other substances to enhance its effects, posing significant health risks and potential for abuse.

InChI:InChI=1/C13H20N2O2/c1-16-10-11-17-13-4-2-12(3-5-13)15-8-6-14-7-9-15/h2-5,14H,6-11H2,1H3

Upstream product

• 110-85-0 piperazine 
• 39255-23-7 1-Bromo-4-(2-Methoxyethoxy)-benzene 
• 158985-25-2 tert-butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate 
• 106-41-2 4-bromo-phenol 
• 67914-60-7 N-acetyl-N'-(4-hydroxyphenyl)piperazine 
• 387358-27-2 1-{4-[4-(2-methoxy-ethoxy)-phenyl]-piperazin-1-yl}-ethanone 

Downstream Products

• 377727-87-2 preladenant 
• 1135433-94-1 C₁₅H₂₃ClN₂O₂ 
• 1135433-95-2 2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethan-1-ol 

Relevant articles and documents

PYRAZOLOTRIAZOLOPYRIMIDINE DERIVATIVES AS A2A RECEPTOR ANTAGONIST

Disclosed herein is a pyrazolotriazolopyrimidine derivative or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof useful as A2A receptor antagonist, and a pharmaceutical composition comprising the same. Also disclosed herein is a method of treating cancer using the pyrazolotriazolopyrimidine derivative or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof as A2A receptor antagonist.

3H-[1,2,4]-Triazolo[5,1-i]purin-5-amine derivatives as adenosine A2A antagonists

A novel series of 3-substituted-8-aryl-[1,2,4]-triazolo[5,1-i]purin-5-amine analogs related to Sch 58261 was synthesized in order to identify potent adenosine A2A receptor antagonists with improved selectivity over the A1 receptor, physiochemical properties, and pharmacokinetic profiles as compared to those of Sch 58261. As a result of structural modifications, numerous analogs with excellent in vitro binding affinities and selectivities were identified. Moreover, compound 27 displayed both superior in vitro and highly promising in vivo profiles.

2-(2-Furanyl)-7-phenyl[1,2,4]triazolo[1,5-c]pyrimidin-5-amine analogs: Highly potent, orally active, adenosine A2A antagonists. Part 1

The structure-activity relationship of this novel class of compounds based on 2-(2-furanyl)-7-phenyl[1,2,4]-triazolo[1,5-c]pyrimidin-5-amine, 1, and its analogs was evaluated for their in vitro and in vivo adenosine A2A receptor antagonism. Several compounds displayed oral activity at 3 mg/kg in a rat catalepsy model. Specifically, compound 8g displayed an excellent in vitro profile, as well as a highly promising in vivo profile.