51517-45-4

Usage

Uses

Used in Organic Synthesis:
2-(11-Hydroxy-3-oxo-3H-dibenzo[c,h]xanthen-7-yl)benzoic acid is used as a key intermediate in the synthesis of various organic compounds. Its unique molecular structure allows for versatile chemical reactions, making it a valuable building block for the development of new organic molecules with potential applications in various industries.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 2-(11-Hydroxy-3-oxo-3H-dibenzo[c,h]xanthen-7-yl)benzoic acid is utilized as a starting material for the development of new drugs. Its unique molecular structure and properties can be exploited to design and synthesize novel pharmaceutical compounds with potential therapeutic applications.
Used in Dye Manufacturing:
2-(11-Hydroxy-3-oxo-3H-dibenzo[c,h]xanthen-7-yl)benzoic acid, being a member of the xanthene dyes family, is used in the manufacturing of dyes for various applications, including textiles, plastics, and printing inks. Its vibrant color and chemical stability make it a suitable choice for these industries.
Used in Analytical Chemistry:
Due to its unique chemical properties, 2-(11-Hydroxy-3-oxo-3H-dibenzo[c,h]xanthen-7-yl)benzoic acid can be employed as a reagent or indicator in various analytical techniques. It can be used to detect or quantify specific substances in chemical analysis, providing valuable information for research and quality control purposes.
Used in Research and Development:
In the field of research and development, 2-(11-Hydroxy-3-oxo-3H-dibenzo[c,h]xanthen-7-yl)benzoic acid serves as a valuable compound for studying the properties and behavior of xanthene dyes and their derivatives. Its unique molecular structure offers opportunities for exploring new chemical reactions, synthesis methods, and potential applications in various fields.

InChI:InChI=1/C28H16O5/c29-17-7-11-19-15(13-17)5-9-23-25(21-3-1-2-4-22(21)28(31)32)24-10-6-16-14-18(30)8-12-20(16)27(24)33-26(19)23/h1-14,29H,(H,31,32)

Upstream product

• 1512865-39-2 3,11-bis((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)oxy)-3′H-spiro-[dibenzo[c,h]xanthene-7,1′-isobenzofuran]-3′-one 
• 85-44-9 phthalic anhydride 
• 575-44-0 1,6-dihydroxynaphthalene 
• 1094711-51-9 naphtho-peroxyfluor-1 
• 61419-02-1 naphthofluorescein 
• 874657-97-3 C₄₂H₂₈O₉S₂ 

Downstream Products

• 1380077-15-5 methyl 2-(11-hydroxy-3-oxo-3H-dibenzo[c,h]xanthen-7-yl)benzoate 

Relevant academic research and scientific papers

A near-infrared naphthofluorescein-based fluorescent probe for hydrogen sulfide detection

A simple naphthofluorescein-based probe was designed and synthesized by a two-step method. As expected, there was a good linear relationship between fluorescence intensity (680 nm)/absorbance (640 nm) and H2S concentration in the range of 2.00–10.0 μM with a detection limit of 0.50 μM/0.10 μM (S/N = 3). This probe was applied to monitor H2S concentration in red wine samples. Furthermore, it was successfully used to image exogenous H2S in living Hela cells, indicating its potential application in biology and medicine.

A red-emitting naphthofluorescein-based fluorescent probe for selective detection of hydrogen peroxide in living cells

We report the synthesis, properties, and cellular application of Naphtho-Peroxyfluor-1 (NPF1), a new fluorescent indicator for hydrogen peroxide based on a red-emitting naphthofluorescein platform. Owing to its boronate cages, NPF1 features high selectivity for hydrogen peroxide over a panel of biologically relevant reactive oxygen species (ROS), including superoxide and nitric oxide, as well as excitation and emission profiles in the far-red region of the visible spectrum (>600 nm). Flow cytometry experiments in RAW264.7 macrophages establish that NPF1 can report changes in peroxide levels in living cells.

Strong red fluorescent probes suitable for detecting hydrogen peroxide generated by mice peritoneal macrophages

This paper reports the synthesis, fluorescence properties, and biological applications of naphthofluorescein disulfonate (NFDS-1), as a red fluorescence imaging probe to detect intracellular H2O2. The Royal Society of Chemistry 2005.

NBD-based colorimetric and fluorescent turn-on probes for hydrogen sulfide

Hydrogen sulfide (H2S) is an important endogenous signalling molecule and also an important environmental target for detection. New reaction-based colorimetric and fluorescent turn-on probes based on selective thiolyling of NBD (7-nitro-1,2,3-benzoxadiazole) ether were explored for sensing of H2S in aqueous buffer. The syntheses of both probes are simple and quite straightforward. The probes are highly sensitive and selective toward H2S over other biologically relevant species. Probe 1 can be used to directly visualize H2S by the naked eye and shows more than 1000-fold fluorescence increase upon reaction with H2S. Probe 2 is a near-infrared fluorescent sensor for H2S at physiological pH.