51521-29-0

Usage

Synthesis Reference(s)

Synthesis, p. 389, 1988 DOI: 10.1055/s-1988-27585

Upstream product

• 82911-07-7 N,N'-bis<2-(dimethoxy)ethyl>-p-xylene-α,α'-diamine dihydrochloride 
• 85575-12-8 2,5-dichloro-N,N'-bis<2-(dimethoxy)ethyl>-p-xylene-α,α'-diamine dihydrochloride 
• 117727-15-8 5,10-Dioxo-5,10-dihydropyrido<3,4-g>isoquinoline 
• 117727-16-9 5,10-Dihydropyrido<3,4-g>isoquinoline 
• 85575-09-3 N,N'-bis<2-(diethoxy)ethyl>-p-xylene-α,α'-diamine dihydrochloride 
• 85575-13-9 5,10-dichloropyrido<3,4-g>isoquinoline 

Relevant academic research and scientific papers

MODULATORS OF THE GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-KB ACTIVITY AND USE THEREOF

A class of novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-?B activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I) its stereoisomers thereof, or a solvate thereof, or a prodrug thereof, or a pharmaceutically acceptable salt thereof, where Z is CONR1R2 or CH2NR1R2 and where at least one of X1 - X8 is N, and R, Ra, Rb, Rc and Rd are defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.

Organic photochromic compound, a dimer of pyrido quinoline

An organic photochromic compound with improved long term preservability, thermal stability, the repetition character of the record and the like and useful as recording-memory materials or photosensitizers, comprising dimers of the compounds selected from the group consisting of pyrido[3,4-g]isoquinoline, pyrido[2,3-g]quinoline, pyrido[3,2-g]quinoline and pyrido[3,2-g]quinoline derivatives.

A Convenient Synthesis of Pyridoisoquinoline via ortho-Directed Metallation/Dimerization

A practical synthesis of pyridoisoquinoline was realized by a novel ortho-metallation/dimerization of N,N-diethylnicotinamide (or N,N-diethylisonicotinamide), hydriodic acid reduction of the resultant diazaanthraquinone, and catalytic dehydrogenation.

The Cyclization of N,N'-Bisisoquinoline and 3,8-Phenanthroline

The ring closure of N,N'-bis-p-xylene-α,α'-diamine dihydrochloride in fuming sulfuric acid has been investigated and the cyclization products have been identified as the linear pyridoisoquinoline as well as the previously reporte