51523-49-0

Basic information

• Product Name: Piperidine, 2-(cyclohexylmethyl)-
• Synonyms: 2-(CYCLOHEXYLMETHYL)PIPERIDINE
• CAS NO: 51523-49-0
• Molecular Formula: C₁₂H₂₃N
• Molecular Weight: 181.32
• Mol File: 51523-49-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Piperidine, 2-(cyclohexylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidine, 2-(cyclohexylmethyl)-(51523-49-0)
• EPA Substance Registry System: Piperidine, 2-(cyclohexylmethyl)-(51523-49-0)

Safety Data

• Hazardous Substances Data: 51523-49-0(Hazardous Substances Data)

Usage

General Description

Piperidine, 2-(cyclohexylmethyl)- is a chemical compound that belongs to the class of piperidine derivatives. It is also known as N-cyclohexylmethylpiperidine and is commonly used in pharmaceutical research as a building block for the synthesis of various drugs and other biologically active compounds. Piperidine, 2-(cyclohexylmethyl)- has been found to exhibit analgesic and anti-inflammatory properties, making it potentially useful in the development of new pain-relieving medications. Additionally, it has been studied for its potential as a catalyst in organic chemistry reactions. Overall, piperidine, 2-(cyclohexylmethyl)- plays a significant role in the field of medicinal chemistry and drug discovery.

Upstream product

• 101-82-6 2-Benzylpyridine 
• 108-85-0 1-bromocyclohexane 
• 109-06-8 α-picoline 
• 57756-06-6 2-(cyclohexylmethyl)pyridine 

Downstream Products

• 60695-21-8 2-cyclohexylmethyl-1-[α-(3-benzoylphenyl)propionyl]piperidine 
• 60695-24-1 2-cyclohexylmethyl-1-{2-[3-(α-hydroxybenzyl)phenyl]ethyl}piperidine 
• 60695-23-0 2-cyclohexylmethyl-1-[(3-benzoylphenyl)acetyl]piperidine 
• 60601-82-3 2-cyclohexylmethyl-1-[2-(3-bromophenyl)propyl]-piperidine 
• 60601-66-3 2-cyclohexylmethyl-1-[2-(4-isobutylphenyl)propyl]piperidine 
• 1228934-93-7 6-{2-[2-(cyclohexylmethyl)piperidin-1-yl]-2-oxoethyl}-4-(1H-indol-3-ylmethyl)-1-phenyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one 
• 7394-61-8 1-(2-cyclohexylmethylpiperidino)pentan-4-one 
• 60695-22-9 2-cyclohexylmethyl-1-{2-[3-(α-hydroxybenzyl)phenyl]propyl}piperidine 
• 60695-62-7 2-cyclohexylmethyl-1-[2-(3-benzoylphenyl)propyl]piperidine 
• 60695-61-6 2-cyclohexylmethyl-1-[2-(3-benzylphenyl)propyl]piperidine 
• 60695-78-5 {3-[2-(2-Cyclohexylmethyl-piperidin-1-yl)-ethyl]-phenyl}-phenyl-methanone 
• 60601-71-0 1-[(E)-2-(3-Bromo-phenyl)-propenyl]-2-cyclohexylmethyl-piperidine 

Relevant articles and documents

Hydrogenation of 2-benzylpyridine over alumina-supported Ru catalysts: Use of Ru3(CO)12 as a Ru precursor

Although Ru3(CO)12 becomes a popular precursor for supported Ru catalysts nowadays, the activities of the catalysts prepared by thermolysis of the supported Ru3(CO)12 under different atmospheres have been rarely compared. We herein report the preparation of alumina-supported Ru samples by thermal activation of Ru3(CO)12 in air, H2 or N2, followed by activity test in the hydrogenation of 2-benzylpyridine (BPy). When the supported Ru3(CO)12 was activated in air, RuO2 particles of 12–15 nm diameters were produced by complete oxidation of carbonyl groups. In contrast, thermal activation in H2 and N2 induced the formation of highly dispersed Ru0 particles of 1.4–2.3 nm diameters. In such activations methane was produced, suggesting that direct hydrogenation of CO coordinated to the Ru surface complex occurred in H2 while the coordinated CO reacted with ruthenium hydride species in N2. In the activity test for BPy hydrogenation, the samples prepared in H2 and N2 showed superior H2 storage efficiencies and higher rate constants compared to those prepared in air (reduced before the reaction). Additionally, the former samples were examined to be relatively stable even though exposed to ambient air for 7 days. Therefore, H2 and N2 gases are recommended for thermal activation of alumina-supported Ru3(CO)12.

Phenyl-lower-alkylamines

Phenyl-lower-alkylamines having anti-inflammatory activity are prepared either by reductive alkylation of an amine with a phenyl-lower-alkanaldehyde; by condensation of a phenyl-lower-alkanaldehyde with a secondary amine, conversion of the resulting phenylvinylamine to the corresponding iminium salt, and reduction of the latter with an alkali metal borohydride; or by reaction of a phenyl-lower-alkanoyl halide with an amine and reduction of the resulting amide with a reagent effective to reduce an amide to an amine.