51523-49-0

Usage

Uses

Used in Pharmaceutical Industry:
Piperidine, 2-(cyclohexylmethyl)is used as a building block for the synthesis of various drugs and biologically active compounds due to its versatile chemical structure and potential therapeutic properties.
Used in Medicinal Chemistry Research:
Piperidine, 2-(cyclohexylmethyl)is used as a research compound for the development of new pain-relieving medications, given its analgesic and anti-inflammatory properties.
Used in Organic Chemistry:
Piperidine, 2-(cyclohexylmethyl)is studied for its potential as a catalyst in organic chemistry reactions, contributing to the advancement of chemical synthesis processes.

Upstream product

• 57756-06-6 2-(cyclohexylmethyl)pyridine 
• 108-85-0 1-bromocyclohexane 
• 101-82-6 2-Benzylpyridine 
• 109-06-8 α-picoline 

Downstream Products

• 60695-78-5 {3-[2-(2-Cyclohexylmethyl-piperidin-1-yl)-ethyl]-phenyl}-phenyl-methanone 
• 60695-61-6 2-cyclohexylmethyl-1-[2-(3-benzylphenyl)propyl]piperidine 
• 60695-62-7 2-cyclohexylmethyl-1-[2-(3-benzoylphenyl)propyl]piperidine 
• 60695-24-1 2-cyclohexylmethyl-1-{2-[3-(α-hydroxybenzyl)phenyl]ethyl}piperidine 
• 60695-22-9 2-cyclohexylmethyl-1-{2-[3-(α-hydroxybenzyl)phenyl]propyl}piperidine 
• 7394-61-8 1-(2-cyclohexylmethylpiperidino)pentan-4-one 
• 1228934-93-7 6-{2-[2-(cyclohexylmethyl)piperidin-1-yl]-2-oxoethyl}-4-(1H-indol-3-ylmethyl)-1-phenyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one 
• 60601-82-3 2-cyclohexylmethyl-1-[2-(3-bromophenyl)propyl]-piperidine 
• 60601-66-3 2-cyclohexylmethyl-1-[2-(4-isobutylphenyl)propyl]piperidine 
• 60695-23-0 2-cyclohexylmethyl-1-[(3-benzoylphenyl)acetyl]piperidine 
• 60695-21-8 2-cyclohexylmethyl-1-[α-(3-benzoylphenyl)propionyl]piperidine 
• 60601-71-0 1-[(E)-2-(3-Bromo-phenyl)-propenyl]-2-cyclohexylmethyl-piperidine 

Relevant academic research and scientific papers

Hydrogenation of 2-benzylpyridine over alumina-supported Ru catalysts: Use of Ru3(CO)12 as a Ru precursor

Although Ru3(CO)12 becomes a popular precursor for supported Ru catalysts nowadays, the activities of the catalysts prepared by thermolysis of the supported Ru3(CO)12 under different atmospheres have been rarely compared. We herein report the preparation of alumina-supported Ru samples by thermal activation of Ru3(CO)12 in air, H2 or N2, followed by activity test in the hydrogenation of 2-benzylpyridine (BPy). When the supported Ru3(CO)12 was activated in air, RuO2 particles of 12–15 nm diameters were produced by complete oxidation of carbonyl groups. In contrast, thermal activation in H2 and N2 induced the formation of highly dispersed Ru0 particles of 1.4–2.3 nm diameters. In such activations methane was produced, suggesting that direct hydrogenation of CO coordinated to the Ru surface complex occurred in H2 while the coordinated CO reacted with ruthenium hydride species in N2. In the activity test for BPy hydrogenation, the samples prepared in H2 and N2 showed superior H2 storage efficiencies and higher rate constants compared to those prepared in air (reduced before the reaction). Additionally, the former samples were examined to be relatively stable even though exposed to ambient air for 7 days. Therefore, H2 and N2 gases are recommended for thermal activation of alumina-supported Ru3(CO)12.

3-(Piperidino-lower-alkyl)-indoles

1-Acyl-3-(amino-lower-alkyl)indoles, useful as anti-inflammatory agents, are prepared either by acylation of a 3-(amino-lower-alkyl)indole; by Fisher indole synthesis from an N'-acylphenylhydrazine and an amino-lower-alkanone; by alkylation of an amine with a 1-acyl-3-(halo-lower-alkyl)indole; or by reductive alkylation of a 1-acyl-3-indole-lower-alkylcarboxaldehyde.

Phenyl-lower-alkylamines

Phenyl-lower-alkylamines having anti-inflammatory activity are prepared either by reductive alkylation of an amine with a phenyl-lower-alkanaldehyde; by condensation of a phenyl-lower-alkanaldehyde with a secondary amine, conversion of the resulting phenylvinylamine to the corresponding iminium salt, and reduction of the latter with an alkali metal borohydride; or by reaction of a phenyl-lower-alkanoyl halide with an amine and reduction of the resulting amide with a reagent effective to reduce an amide to an amine.