51550-10-8

Basic information

• Product Name: 2(3H)-Benzothiazolone,5-(trifluoromethyl)-(9CI)
• Synonyms: 2(3H)-Benzothiazolone,5-(trifluoromethyl)-(9CI);5-Trifluoromethyl-2(3H)-benzothiazolone;5-(Trifluoromethyl)benzo[d]thiazol-2(3H)-one, 97%
• CAS NO: 51550-10-8
• Molecular Formula: C₈H₄F₃NOS
• Molecular Weight: 219.186
• Product Categories: BENZOTHIAZOLE
• Mol File: 51550-10-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.521±0.06 g/cm3(Predicted)
• PKA: 9.48±0.20(Predicted)
• CAS DataBase Reference: 2(3H)-Benzothiazolone,5-(trifluoromethyl)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2(3H)-Benzothiazolone,5-(trifluoromethyl)-(9CI)(51550-10-8)
• EPA Substance Registry System: 2(3H)-Benzothiazolone,5-(trifluoromethyl)-(9CI)(51550-10-8)

Safety Data

• Hazardous Substances Data: 51550-10-8(Hazardous Substances Data)

Usage

Compound family

Benzothiazolone

Contains

Trifluoromethyl group

Potential applications

Pharmaceuticals, agrochemicals, material sciences

Use

Chemical intermediate in the synthesis of other compounds

Modification potential

The presence of the trifluoromethyl group makes it a potential candidate for further modification

Further research needed

To explore the full range of potential applications and uses for this compound.

Upstream product

• 463-58-1 carbon oxide sulfide 
• 7038-40-6 6,6′-disulfanediylbis(3-(trifluoromethyl)aniline) 
• 1202680-24-7 phenyl 4,5-dichloro-6-oxopyridazine-1(6H)-carboxylate 
• 4274-38-8 2-amino-4-(trifluoromethyl)benzenethiol hydrochloride 
• 201230-82-2 carbon monoxide 
• 121-17-5 2-chloro-3-nitro-5-trifluoromethylbenzene 

Downstream Products

• 1234056-34-8 3-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-5-trifluoromethyl-3H-benzothiazol-2-one trifluoroacetate 

Relevant articles and documents

Efficient Synthesis of Benzothiazolone Derivatives by a Domino Reaction of Disulfide and COS under Mild Conditions

Carbonyl sulfide (COS), whose molecular structure is similar to CO2 and CS2, could be used as a better alternative carbonyl reagent due to its high chemical activity. However, the unfriendly by-product H2S would be generated when COS is used as a carbonyl reagent in the carbonylation reaction. In this report, the odorless and stable disulfide was used to replace the traditional foul smelling and unstable o-aminobenzenethiol to react with COS for preparing benzothiazolone derivatives in excellent yield, in which coupling reaction of H2S generation and S–S bond cleavage was firstly designed. Notably, the C=O of COS was converted into benzothiazolone derivatives by carbonylation reaction and the sulfur of COS was transformed into sulfur and sulfide after cleaving the S–S bond by a domino reaction of disulfide and COS under mild conditions. This efficient synthetic methodology provided a promising process for the utilization of COS.

Facile Synthesis of Benzo[ d ]azol-2(3 H)-ones Using 2-Phenoxycarbonyl-4,5-dichloropyridazin-3(2 H)-one as Green CO Source

Developing eco-friendly, stable, and easy-to-handle acyl sources is of great importance in synthetic and green chemistry. This study describes the synthesis of benzo[d]azol-2(3H)-ones such as benzo[d]thiazol-2(3H)-ones, benzo[d]oxazol-2(3H)-ones, and benzo[d]imidazol-2(3H)-ones using 2-phenoxycarbonyl-4,5-dichloropyridazin-3(2H)-one in one pot. The reaction reported is carried out under neutral or acidic conditions in the presence of zinc or sodium bicarbonate to give the corresponding heterocycles in good to excellent yields. The reaction uses a solid stable carbonyl source that is a recyclable functional-group carrier, pyridazin-3(2H)-one.