51552-21-7Relevant academic research and scientific papers
Oximes: Metabolic activation and structure-allergenic activity relationships
Bergstr?m, Moa Andresen,Andersson, Sofia I.,Broo, Kerstin,Luthman, Kristina,Karlberg, Ann-Therese
, p. 2541 - 2550 (2008/12/22)
Metabolic activation of chemicals (prohaptens) in the skin can cause allergic contact dermatitis. We have explored structure-allergenic activity relationships for seven potential oxime prohaptens using the local lymph node assay and a GSH trapping screen
Direct C-nitration of cyclic α,β-unsaturated oximes under the action of sodium nitrite and acetic acid in methanol
Chibiryaev,Denisov,Pyshnyi,Tkachev
, p. 1410 - 1418 (2007/10/03)
Using a number of cyclic α,β-unsaturated oximes of the terpene series and some simplest model compounds as examples, unsaturated oximes bearing a hydrogen atom at the β-carbon atom were demonstrated to be converted into β-hydroxyiminonitroalkenes under the action of sodium nitrite and acetic acid in methanol. In the case of the introduction of an alkyl substituent at the terminal carbon atom of the diene C = C-C=NOH fragment, the reaction performed under the same conditions gave rise exclusively to conjugated ketone (a deoximation product).
REDUCTION OF CONJUGATED CYCLOHEXENONE OXIMES WITH ALUMINIUM HYDRIDE
Zaidlewicz, Marek,Uzarewicz, Ireneusz G.
, p. 143 - 150 (2007/10/02)
The reduction of representative conjugated cyclohexenone oximes with aluminium hydride in tetrahydrofuran yields 2-cyclohexenylamines and saturated aziridines - 7-azabicycloheptane derivatives, as the main reaction products.Small quantities of cyclohexylamines and perhydroazepines are also formed.Regioselectivity of the reduction depends on oxime configuration.Higher yields of 2-cyclohexenylamines are obtained from E than Z isomers.The reaction mechanism is proposed.
