51554-46-2

Upstream product

• 144456-15-5 2-phenyl-9-β-(2′,3′-O-isopropylidene-D-ribofuranosyl)adenine 
• 141018-25-9 (3aR,4R,6R,6aR)-(6-(6-amino-2-iodo-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol 
• 35109-88-7 2-iodoadenosine 

Relevant academic research and scientific papers

Base-modified NAD and AMP derivatives and their activity against bacterial DNA ligases

We report the chemical synthesis and conformational analysis of a collection of 2-, 6- and 8-substituted derivatives of β-NAD+ and AMP, and their biochemical evaluation against NAD+-dependent DNA ligases from Escherichia coli and Myc

ADP and ATP analogues, process for making and administration to inhibit ADP-induced platelet aggregation

There are disclosed compounds of formula I, STR1 wherein Q represents CR 1 R 2,R represents O or CR 3 R 4,W represents O or CH 2,R 1, R 2, R 3 and R 4 independently represent hydrogen or halogen,X represents S(O) n R 5, alkyl C 1-6 alkoxy C 1-6, acylamino C 1-6, CONR 6 R 7, NR 8 R 9, halogen, a 5- or 6-membered S containing heterocycle, or phenyl optionally substituted by alkyl C 1-6,n represents 0, 1 or 2,R 5 represents aryl or alkyl C 1-6 optionally substituted by one or more substituents selected from hydroxy, alkoxy C 1-6, halogen and aryl;R 6, R 7, R 8 and R 9 independently represent hydrogen or alkyl C 1-6,Y represents NH 2 or alkoxy C 1-6, andZ represents an acidic moiety,in addition, when R represents CR 3 R 4, then --Q--Z may also represent hydroxy or --OP(O)(OH) 2,and pharmaceutically acceptable salts thereof, with certain provisos, for use as pharmaceuticals.