51561-20-7

Usage

Uses

Used in Pharmaceutical Industry:
6-AMINO-2-CHLORO-4-METHYLPYRIDINE-3-CARBONITRILE is used as an intermediate in the synthesis of various drugs and pharmaceutical products. Its unique chemical structure and properties make it a valuable component for the production of active pharmaceutical ingredients.
Used in Organic Synthesis:
6-AMINO-2-CHLORO-4-METHYLPYRIDINE-3-CARBONITRILE is used as a versatile reagent in organic synthesis, where its functional groups can be manipulated to create a wide range of chemical compounds.
Used in Medicinal Chemistry:
6-AMINO-2-CHLORO-4-METHYLPYRIDINE-3-CARBONITRILE is utilized in medicinal chemistry for the development of new pharmaceutical agents, taking advantage of its diverse reactivity and functional groups to design and synthesize potential drug candidates.

InChI:InChI=1/C7H6ClN3/c1-4-2-6(10)11-7(8)5(4)3-9/h2H,1H3,(H2,10,11)

Upstream product

• 875-35-4 2,6-dichloro-4-methylnicotinonitrile 
• 5444-02-0 2,6-dihydroxy-3-cyano-4-methylpyrimidine 

Downstream Products

• 894804-37-6 6-amino-2-ethoxy-4-methylnicotinonitrile 

Relevant academic research and scientific papers

SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M4 PAMs

This letter describes progress towards an M4 PAM preclinical candidate inspired by an unexpected aldehyde oxidase (AO) metabolite of a novel, CNS penetrant thieno[2,3-c]pyridine core to an equipotent, non-CNS penetrant thieno[2,3-c]pyrdin-7(6H)-one core. Medicinal chemistry design efforts yielded two novel tricyclic cores that enhanced M4 PAM potency, regained CNS penetration, displayed favorable DMPK properties and afforded robust in vivo efficacy in reversing amphetamine-induced hyperlocomotion in rats.

POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4

Disclosed herein are thieno[3,2-e][1,2,4]triazolo[1,5-a]pyridin-6-amine, thieno[3,2-e][1,2,4]triazolo[4,3-a]pyridin-3-amine, and imidazo[1,2-a]thieno[3,2-e]pyridin-3-amine compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

NEW TRPA1 ANTAGONISTS

The present invention relates to bicyclic heterocyclic derivatives of Forrmula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by TRPA1 channel inhibition or antagonism.

NEW TRPA1 ANTAGONISTS

The present invention relates to compounds of Formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by TRPA1 channel inhibition or antagonism.

Synthesis and Reactivity of 2,6-Diamino-4-methyl-3-pyridinecarbonitrile

2,6-Dihydroxy-4-methyl-3-pyridinecarbonitrile is converted via its 2,6-dichloro analog into the corresponding 2-amino-6-chloro, 2-chloro-6-amino, and 2,6-diamino derivatives.The last reacts with benzenesulfonyl chloride to yield a tris-sulfonyl derivative, the structure of which is demonstrated by X-ray analysis.