51576-05-7Relevant academic research and scientific papers
Metabolism of Steviol and Its Derivatives by Gibberella fujikuroi
Murofushi, Noboru,Shigematsu, Yoshio,Nagura, Shigehiro,Takahashi, Nobutaka
, p. 2305 - 2312 (2007/10/02)
Steviol (ent-13-hydroxykaur-16-en-19-oic acid is metabolized by Gibberella fujikuroi in the presence of inhibitors of gibberellin biosynthesis, such as quaternary ammonium salt-type growth retardants, to afford 7β-hydroxy- and 6β,7β-dihydroxysteviol, gibberellins A1, A18, A19, A53 and 7β,13-dihydroxykaurenolide.Steviol acetate (ent-13-acetoxykaur-16-en-19-oic acid) is also metabolized to the 6β,7β-dihydroxy-derivative and to the 13-acetyl derivatives of gibberellins A17 and A20 and steviol methyl ester (methyl ent-13-hydroxykaur-16-en-19-oate) into the monohydroxy-, dihydroxy- and hydroxyoxo-derivatives.These results indicate a low substrate specificity of the enzymes in the fungus and provide a useful preparative methodology of several important plant gibberellins carrying the 13-hydroxyl group.
