51579-88-5

Upstream product

• 680-31-9 N,N,N,N,N,N-hexamethylphosphoric triamide 
• 349-76-8 3'-(trifluoromethyl)acetophenone 
• 68-12-2 N,N-dimethyl-formamide 
• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 1608-14-6 N,N,N'N'-tetramethyl oxamide 
• 401-79-6 1-methyl-3-trifluoromethyl-benzene 

Relevant academic research and scientific papers

Transition metal-free synthesis of α-ketoamides from arylmethyl ketones and alkylphosphoramides

A transition metal-free protocol has been developed for the synthesis of α-ketoamides from aryl methyl ketones and alkylphosphoramides in the presence of oxidant, aqueous tert-butyl hydroperoxide (TBHP). A series of aryl methyl ketones having both electron-donating as well as electron-withdrawing groups were successfully employed for the synthesis of their corresponding α-ketoamides using hexamethylphosphoramide and other alkylphosphoramides.

TBAI-catalyzed synthesis of α-ketoamides via sp3 C-H radical/radical cross-coupling and domino aerobic oxidation

A TBAI-catalyzed one-pot synthesis of α-ketoamides via sp3 C-H radical/radical cross-coupling and domino aerobic oxidation was developed. This synthesis is suitable for abroad range of substrates. The control experiments suggested a possible oxidative coupling mechanism.

NBu4NI-catalyzed direct synthesis of α-ketoamides from aryl methyl ketones with dialkylformamides in water using TBHP as oxidant

A novel and easy practical direct synthesis of α-ketoamides has been developed without metals in water. This procedure was catalyzed by nBu 4NI using TBHP as oxidant from simple substrates, aryl methyl ketones and dialkylformamides. The Royal Society of Chemistry 2012.