51586-21-1

Usage

Uses

Used in Pharmaceutical Industry:
N-(3-CHLOROBENZYL)-N-CYCLOPROPYLAMINE is used as an intermediate for the synthesis of various organic compounds, contributing to the development of new pharmaceuticals.
Used in Agricultural Industry:
N-(3-CHLOROBENZYL)-N-CYCLOPROPYLAMINE is used as a building block for the production of agrochemicals, aiding in the creation of effective crop protection agents.
Used in Therapeutic Applications:
N-(3-CHLOROBENZYL)-N-CYCLOPROPYLAMINE is studied for its potential therapeutic effects, particularly in the treatment of certain neurological and psychiatric disorders, due to its unique chemical structure and properties.

InChI:InChI=1/C10H12ClN/c11-9-3-1-2-8(6-9)7-12-10-4-5-10/h1-3,6,10,12H,4-5,7H2

Upstream product

• 587-04-2 m-Chlorobenzaldehyde 
• 765-30-0 Cyclopropylamine 

Downstream Products

• 1361293-79-9 N-(3-chlorobenzyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)phenyl)-N-cyclopropyl-6-(hydroxymethyl)-1,2,5,6-tetrahydropyridine-3-carboxamide 
• 1361294-01-0 N-(3-Chlorobenzyl)-N-cyclopropyl-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)phenyl)-2-(hydroxymethyl)-1,2,5,6-tetrahydropyridine-3-carboxamide 

Relevant academic research and scientific papers

Design, Synthesis, and Structure-Activity Relationship of Economical Triazole Sulfonamide Aryl Derivatives with High Fungicidal Activity

Plant fungal diseases have caused great decreases in crop quality and yield. As one of the considerable agricultural diseases, cucumber downy mildew (CDM) caused by pseudoperonospora cubensis seriously influences the production of cucumber. Amisulbrom is a commercial agricultural fungicide developed by Nissan Chemical, Ltd., for the control of oomycetes diseases that is highly effective against CDM. However, the synthesis of amisulbrom has a high cost because of the introduction of the bromoindole ring. In addition, the continuous use of amisulbrom might increase the risk of resistance development. Hence, there is an imperative to develop active fungicides with new scaffolds but low cost against CDM. In this study, a series of 1,2,4-triazole-1,3-disulfonamide derivatives were designed, synthesized, and screened. Compound 1j showed a comparable fungicidal activity with amisulbrom, but it was low cost and ecofriendly. It has the potential to be developed as a new fungicide candidate against CDM. Further investigations of structure-activity relationship exhibited the structural requirements of 1,2,4-triazole-1,3-disulfonamide and appropriate modification in N-alkyl benzylamine groups with high fungicidal activity. This research will provide powerful guidance for the design of highly active lead compounds with a novel skeleton and low cost.

Renin inhibitors

The invention relates to compounds having the formula: wherein the variables are as defined herein. The invention further relates to methods of making and using these compounds, and pharmaceutical compositions, kits and articles of manufacture comprise th

Design and preparation of potent, nonpeptidic, bioavailable renin inhibitors

Starting from known piperidine renin inhibitors, a new series of 3,9-diazabicyclo[3.3.1]nonene derivatives was rationally designed and prepared. Optimization of the positions 3, 6, and 7 of the diazabicyclonene template led to potent renin inhibitors. The substituents attached at the positions 6 and 7 were essential for the binding affinity of these compounds for renin. The introduction of a substituent attached at the position 3 did not modify the binding affinity but allowed the modulation of the ADME properties. Our efforts led to the discovery of compound (+)-26g that inhibits renin with an IC 50 of 0.20 nM in buffer and 19 nM in plasma. The pharmacokinetics properties of this and other similar compounds are discussed. Compound (+)-26g is well absorbed in rats and efficacious at 10 mg/kg in vivo.