51595-08-5Relevant academic research and scientific papers
The tyrosinase-inhibitory effects of 2-phenyl-1,4-naphthoquinone analogs: importance of the (E)-β-phenyl-α,β-unsaturated carbonyl scaffold of an endomethylene type
Ullah, Sultan,Akter, Jinia,Kim, Su J.,Yang, Jungho,Park, Yujin,Chun, Pusoon,Moon, Hyung R.
, p. 95 - 103 (2019)
In order to investigate the effect of the (E)-β-phenyl-α,β-unsaturated carbonyl scaffold of an endomethylene type on tyrosinase inhibition, 2-phenyl-1,4-naphthoquinone derivatives were synthesized by Michael addition of substituted benzenes to 1,4-naphtho
New naphthoquinone derivatives against glioma cells
Redaelli, Marco,Mucignat-Caretta, Carla,Isse, Abdirisak Ahmed,Gennaro, Armando,Pezzani, Raffaele,Pasquale, Riccardo,Pavan, Valeria,Crisma, Marco,Ribaudo, Giovanni,Zagotto, Giuseppe
, p. 458 - 466 (2015/05/05)
This work was aimed to the development of a set of new naphtoquinone derivatives that can act against glioma. The compounds were tested in order to find out their ability to inhibit the growth of glioma cells, and the results of these assays were correlated with electrochemical analysis and NMR-based reoxidation kinetic studies, suggesting that a redox mechanism underlies and may explain the observed biological behavior. In addition to a full description of the synthetic pathways, electrochemistry, NMR and single crystal X-ray diffraction data are provided.
