51596-37-3Relevant academic research and scientific papers
Facile assembly of fused benzofuro-heterocycles
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Page/Page column 7; 15, (2009/04/24)
This invention concerns the synthesis of polycyclic structural components of pharmacological compounds, including the synthesis of fused benzofuro-heterocycles, through selective palladium-catalyzed cross-coupling and intramolecular cyclization.
Facile assembly of fused benzo[4,5]furo heterocycles
Liu, Jing,Fitzgerald, Anne E.,Mani, Neelakandha S.
, p. 2951 - 2954 (2008/09/19)
(Chemical Equation Presented) A concise synthesis of fused benzo[4,5]furo heterocycles 18 has been developed. Chemo/regioselective Suzuki coupling between 1,2-dihaloarene 17 and α-hydroxyphenylboronic acid or ester 20 gives biaryl phenol 19, which then undergoes copper(I) thiophene-2-carboxylate (CuTC)-mediated intramolecular cyclization to afford 18 in good overall yield. This method has broad substrate scope and allows facile assembly of a wide variety of benzo[4,5]furo heterocycles.
