51605-33-5

Usage

Uses

Used in Organic Synthesis:
5-(Chloromethyl)-4-methyl-1H-imidazole hydrochloride is used as a reagent in organic synthesis for its ability to participate in a variety of chemical reactions, contributing to the formation of new compounds with potential applications in different fields.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 5-(Chloromethyl)-4-methyl-1H-imidazole hydrochloride is utilized as a research compound to explore its potential in drug development. Its imidazole structure, which is known for exhibiting antimicrobial properties, makes it a candidate for further investigation into its possible use in creating antifungal and antibacterial agents.
Used in Antifungal and Antibacterial Development:
5-(Chloromethyl)-4-methyl-1H-imidazole hydrochloride is considered for use as a precursor in the development of antifungal and antibacterial agents due to the antimicrobial nature of imidazole compounds. Its unique structure allows for the potential creation of new treatments for various microbial infections.
Used in Laboratory Applications:
The hydrochloride salt form of 5-(Chloromethyl)-4-methyl-1H-imidazole offers greater stability and solubility in water, making it easier to handle in laboratory settings. It is used for various experimental procedures that require a stable and soluble imidazole derivative.

InChI:InChI=1/C5H7ClN2.ClH/c1-4-5(2-6)8-3-7-4;/h3H,2H2,1H3,(H,7,8);1H

Upstream product

• 822-36-6 4-methyl-1H-imidazole 
• 38585-62-5 4-hydroxymethyl-5-methylimidazole hydrochloride 
• 60-29-7 diethyl ether 
• 7732-18-5 water 
• 51605-32-4 ethyl 4⁽⁵⁾-methylimidazole-5⁽⁴⁾-carboxylate 
• 51605-32-4 Ethyl 5-Methyl-4-imidazolecarboxylate 
• 29636-87-1 4⁽⁵⁾-methyl-5⁽⁴⁾-hydroxymethylimidazole 
• 38585-62-5 4-methyl-5-hydroxymethyl-imidazole hydrochloride 

Downstream Products

• 118796-97-7 1-methyl-2-(4methyl-5-imidazolylmethyl)isothiourea dihydrochloride 
• 38603-72-4 4-Methyl-5-[(2-amino-ethyl)thiomethyl]-imidazole dihydrochloride 
• 51481-61-9 Cimetidine 
• 155795-83-8 4-chloromethyl-5-methyl-1-(4-methylbenzenesulphonyl)-imidazole 
• 53316-51-1 4,5-dimethyl-1H-imidazole hydrochloride 
• 51481-61-9 Cimetidine 
• 51667-66-4 4⁽⁵⁾-(cyanomethyl)-5⁽⁴⁾-methylimidazole 
• 2302-39-8 4,5-dimethylimidazole 
• 38585-62-5 4-methyl-5-hydroxymethyl-imidazole hydrochloride 
• 26364-65-8 2-(cyanoimino)-thiazolidine 
• 118796-95-5 1-phenyl-2-(4-methyl-5-imidazolylmethyl)isothiourea dihydrochloride 
• 51667-66-4 4⁽⁵⁾-(cyanomethyl)-5⁽⁴⁾-methylimidazole 
• 118796-98-8 1-allyl-2-(4-methyl-5-imidazolylmethyl)isothiourea dihydrochloride 

Relevant academic research and scientific papers

IONIC COMPOSITIONS AND RELATED USES THEREOF

The present disclosure generally relates to ionic compositions which may be used in or as an adhesive material for selectively adhering two items together. More particularly, but not exclusively, the present disclosure relates to ionic compositions that include a cationic imidazolium compound and an anionic compound such as a sulfonyl imide compound.

Halogen bond anion templated assembly of an imidazolium pseudorotaxane

Halogen bonding has been exploited in the assembly of an interpenetrated molecular system. The strength of chloride-anion-templated pseudorotaxane formation with a 2-bromo-functionalized imidazolium threading component and an isophthalamide macrocycle (see picture) is significantly enhanced compared to hydrogen-bonded pseudorotaxane analogues. (Figure Presented).

Thiazole as a Carbonyl Bioisostere. A Novel Class of Highly Potent and Selective 5-HT3 Receptor Antagonists

A novel structural class of highly potent and selective 5-HT3 receptor antagonists is described.The compounds in this new series contain a thiazole moiety linking an aromatic group and a nitrogen-containing basic region; the thiazole group appears to be acting as a carbonyl bioisostere in this system.An optimized member of this series, 4-(2-methoxyphenyl)-2-methyl>thiazole (5), exhibits oral activity in the Bezold-Jarisch reflex paradigm comparable to or better than the standard agents ondansetron (1) and ICS-205-930 (2).Several of the structure-activity relationships are rationalized in terms of a computer pharmacophore model for 5-HT3 receptor binding.

Synthesis, in vitro binding profile, and central nervous system penetrability of the highly potent 5-HT3 receptor antagonist [3H]-4-(2-methoxyphenyl)-2-[4(5)-methyl-5(4)-imidazolylmethyl]thiazol e

4-(2-Methoxyphenyl)-2-[4(5)-methyl-5(4)-imidazolylmethyl]thiazole (5) is a highly potent member of a structurally novel series of selective serotonin-3 receptor antagonists. The synthesis of tritriated 5 and its binding profile in neuroblastoma-glioma 108

Photographic reagent tetrazoles

There are described novel photographic products and processes which utilize compounds which release a photographic reagent in the presence of alkali. The compounds include an imidazole blocking group and cleave in alkali to release the photographic reagent. Also described are novel compounds.

Conformationally restricted histamine H2 -receptor antagonists containing a tropane ring

Histamine H2 -receptor antagonists having the formula STR1 wherein R1 represents C1 -C4 alkyl or benzyl, R2 represents hydrogen or C1 -C4 alkyl, and Het represents an imidazole, pyrazole, pyrimidine, pyrazine, pyridazine, thiazole, isothiazole, oxazole, isoxazole, triazole, thiadiazole, benzimidazole, or furan ring either unsubstituted or substituted with a C1 -C4 alkyl, hydroxyl, trifluoromethyl, benzyl, halogen, amino, or dimethylaminomethyl group are disclosed along with a synthetic method of producing such compounds and their use as gastric-acid-production inhibitors.

Synthesis of cimetidine

A simple and economical synthesis of cimetidine is described. It is based on the reaction of 4-halomethyl-5-methylimidazole with N-cyano-N'-methyl-N''-(2 mercaptoethyl)guanidine in water-ethanol at pH 9.0 ± 0.3. Pure crystalline cimetidine is obtained in about 75% yield.

Preparation of 4-methyl-5-chloromethyl-imidazole

4-Methyl-5-chloromethyl-imidazole is prepared in the form of its hydrochloride by direct chloromethylation of 4-methyl-imidazole, thus becoming readily available industrially as an intermediate.