51605-33-5

Basic information

• Product Name: 5-(Chloromethyl)-4-methyl-1H-imidazole hydrochloride
• Synonyms: 5-(Chloromethyl)-4-methyl-1H-imidazole hydrochloride;1H-imidazole, 5-(chloromethyl)-4-methyl-;4-(chloroMethyl)-5-Methyl-1H-iMidazole hydrochloride (SALTDATA: HCl);4-(chloromethyl)-5-methyl-1H-imidazole hydrochloride
• CAS NO: 51605-33-5
• Molecular Formula: C₅H₇ClN₂*ClH
• Molecular Weight: 167.03642
• Mol File: 51605-33-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 355.5°C at 760 mmHg
• Flash Point: 168.8°C
• Appearance: /
• Vapor Pressure: 2.18E-05mmHg at 25°C
• CAS DataBase Reference: 5-(Chloromethyl)-4-methyl-1H-imidazole hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(Chloromethyl)-4-methyl-1H-imidazole hydrochloride(51605-33-5)
• EPA Substance Registry System: 5-(Chloromethyl)-4-methyl-1H-imidazole hydrochloride(51605-33-5)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 51605-33-5(Hazardous Substances Data)

Usage

General Description

5-(Chloromethyl)-4-methyl-1H-imidazole hydrochloride is a chemical compound with the molecular formula C6H7ClN2. It is a derivative of imidazole and contains a chloromethyl group and a methyl group. 5-(Chloromethyl)-4-methyl-1H-imidazole hydrochloride is typically found in the form of a white to off-white crystalline powder. It is commonly used as a reagent in organic synthesis and pharmaceutical research. Additionally, it may also have potential applications in the development of antifungal and antibacterial agents due to its imidazole structure, which is known to exhibit antimicrobial properties. The hydrochloride salt form of 5-(Chloromethyl)-4-methyl-1H-imidazole is more stable and has greater solubility in water, making it easier to handle and use in various laboratory applications.

InChI:InChI=1/C5H7ClN2.ClH/c1-4-5(2-6)8-3-7-4;/h3H,2H2,1H3,(H,7,8);1H

Upstream product

• 822-36-6 4-methyl-1H-imidazole 
• 60-29-7 diethyl ether 
• 7732-18-5 water 
• 51605-32-4 ethyl 4⁽⁵⁾-methylimidazole-5⁽⁴⁾-carboxylate 
• 51605-32-4 Ethyl 5-Methyl-4-imidazolecarboxylate 
• 38585-62-5 4-hydroxymethyl-5-methylimidazole hydrochloride 
• 29636-87-1 4⁽⁵⁾-methyl-5⁽⁴⁾-hydroxymethylimidazole 
• 38585-62-5 4-methyl-5-hydroxymethyl-imidazole hydrochloride 

Downstream Products

• 118796-97-7 1-methyl-2-(4methyl-5-imidazolylmethyl)isothiourea dihydrochloride 
• 155795-83-8 4-chloromethyl-5-methyl-1-(4-methylbenzenesulphonyl)-imidazole 
• 26364-65-8 2-(cyanoimino)-thiazolidine 
• 38603-72-4 4-Methyl-5-[(2-amino-ethyl)thiomethyl]-imidazole dihydrochloride 
• 53316-51-1 4,5-dimethyl-1H-imidazole hydrochloride 
• 2302-39-8 4,5-dimethylimidazole 
• 118796-95-5 1-phenyl-2-(4-methyl-5-imidazolylmethyl)isothiourea dihydrochloride 
• 51667-66-4 4⁽⁵⁾-(cyanomethyl)-5⁽⁴⁾-methylimidazole 
• 51481-61-9 Cimetidine 
• 51667-66-4 4⁽⁵⁾-(cyanomethyl)-5⁽⁴⁾-methylimidazole 
• 118796-98-8 1-allyl-2-(4-methyl-5-imidazolylmethyl)isothiourea dihydrochloride 
• 38585-62-5 4-methyl-5-hydroxymethyl-imidazole hydrochloride 
• 51481-61-9 Cimetidine 

Relevant articles and documents

IONIC COMPOSITIONS AND RELATED USES THEREOF

The present disclosure generally relates to ionic compositions which may be used in or as an adhesive material for selectively adhering two items together. More particularly, but not exclusively, the present disclosure relates to ionic compositions that include a cationic imidazolium compound and an anionic compound such as a sulfonyl imide compound.

Thiazole as a Carbonyl Bioisostere. A Novel Class of Highly Potent and Selective 5-HT3 Receptor Antagonists

A novel structural class of highly potent and selective 5-HT3 receptor antagonists is described.The compounds in this new series contain a thiazole moiety linking an aromatic group and a nitrogen-containing basic region; the thiazole group appears to be acting as a carbonyl bioisostere in this system.An optimized member of this series, 4-(2-methoxyphenyl)-2-methyl>thiazole (5), exhibits oral activity in the Bezold-Jarisch reflex paradigm comparable to or better than the standard agents ondansetron (1) and ICS-205-930 (2).Several of the structure-activity relationships are rationalized in terms of a computer pharmacophore model for 5-HT3 receptor binding.

Synthesis, in vitro binding profile, and central nervous system penetrability of the highly potent 5-HT3 receptor antagonist [3H]-4-(2-methoxyphenyl)-2-[4(5)-methyl-5(4)-imidazolylmethyl]thiazol e

4-(2-Methoxyphenyl)-2-[4(5)-methyl-5(4)-imidazolylmethyl]thiazole (5) is a highly potent member of a structurally novel series of selective serotonin-3 receptor antagonists. The synthesis of tritriated 5 and its binding profile in neuroblastoma-glioma 108