51619-55-7

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(1-HEXYL)-PIPERAZINE is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the psychoactive properties of the final products. Its presence in these compounds can potentially enhance their efficacy in treating specific mental health disorders.
Used in Mental Health Treatment:
1-(1-HEXYL)-PIPERAZINE is used as a therapeutic agent in the treatment of certain mental health disorders due to its psychoactive effects. 1-(1-HEXYL)-PIPERAZINE's structure allows it to interact with neurotransmitter systems in the brain, which can help in managing symptoms associated with these conditions.
Used in Organic Compound Production:
1-(1-HEXYL)-PIPERAZINE is used as an intermediate in the production of other organic compounds, showcasing its importance in the broader scope of chemical synthesis. Its versatile chemical properties make it a valuable component in creating a wide range of products across different industries.

InChI:InChI=1/C10H22N2/c1-2-3-4-5-8-12-9-6-11-7-10-12/h11H,2-10H2,1H3

Upstream product

• 110-89-4 piperidine 
• 109-67-1 1-penten 
• 201230-82-2 carbon monoxide 
• 110-85-0 piperazine 
• 111-25-1 1-bromo-hexane 

Downstream Products

• 1027237-89-3 Acetic acid 4-(4-hexyl-piperazine-1-carbonyl)-phenyl ester 
• 1333141-80-2 C₂₃H₃₆N₆O₂S 
• 339074-49-6 N'-(4-formylphenyl)-N-hexylpiperazine 
• 42992-87-0 N-hexyl-N'-benzylpiperazine 
• 344448-95-9 (4-Hexyl-piperazin-1-yl)-(4-hydroxy-phenyl)-methanone 

Relevant academic research and scientific papers

Novel Naphthalimide Aminothiazoles as Potential Multitargeting Antimicrobial Agents

A series of novel naphthalimide aminothiazoles were developed for the first time and evaluated for their antimicrobial activity. Some prepared compounds possessed good inhibitory activity against the tested bacteria and fungi. Noticeably, the piperazine derivative 4d displayed superior antibacterial activity against MRSA and Escherichia coli with MIC values of 4 and 8 μg/mL, respectively, to reference drugs. The most active compound 4d showed low toxicity against mammalian cells with no obvious triggering of the development of bacterial resistance, and it also possessed rapid bactericidal efficacy and efficient membrane permeability. Preliminarily investigations revealed that compound 4d could not only bind with gyrase-DNA complex through hydrogen bonds but could effectively intercalate into MRSA DNA to form 4d-DNA supramolecular complex, which might be responsible for the powerful bioactivity. Further transportation behavior evaluation indicated that molecule 4d could be effectively stored and carried by human serum albumin, and the hydrophobic interactions and hydrogen bonds played important roles in the binding process.

Synthesis of biologically active amines via rhodium-bisphosphite-catalyzed hydroaminomethylation

(Chemical Equation Presented) We report the use of a highly regioselective rhodium-bisphosphite catalyst for olefin hydroaminomethylation. This catalyst system was successfully applied in the synthesis of two biologically active tertiary amines, ibutilide and aripiprazole.