51620-88-3Relevant academic research and scientific papers
Quinazolinone Alkaloid Febrifugine and Its Analogues To Control Phytopathogenic Diseases Caused by Oomycete Fungi
Fehr, Marcus,Koch, Andreas,Merget, Benjamin,Winter, Christian
, (2022/04/09)
Controlling phytopathogenic diseases caused by oomycete fungi is still a challenge in crop protection research. Studies on identifying new starting points to control phytopathogens revealed that the quinazolinone alkaloids febrifugine (1) and halofuginone (2) are efficiently inhibiting the growth of Phytophthora infestans in microtiter tests. However, despite the very good in vitro activity of 0.13 and 0.06 ppm in IC50, respectively, both compounds did not exhibit a good control of P. infestans on tomato plants. Creating a homology model of prolyl-tRNA synthetase – the molecular target of halofuginone – helped to understand the interactions between 2 and the binding pocket and guided the synthesis of further derivatives. Ultimately, we found that deoxy-febrifugine (14) and halofuginol (17) and its derivatives were able to control P. infestans also on the plant.
Silver-catalyzed cyclization of acetylenic alcohols: Synthesis of functionalized 2-methylene-oxolanes
Pale, Patrick,Chuche, Josselin
, p. 1019 - 1025 (2007/10/03)
Silver salts which have a basic counter-ion are efficient catalysts for the regiospecific intramolecular addition of various acetylenic alcohols. Silver carbonate in aromatic solvent proved to be the best catalyst. Alkynols in which the two reacting parts
Iodonium-induced Cyclisations of 5-Silylalk-4-enols
Schaumann, Ernst,Kirschning, Andreas
, p. 1481 - 1483 (2007/10/02)
In the presence of hypervalent iodine reagents, silyl-substituted δ,ε-unsaturated alcohols (4a-f) underwent ring-closure to give the pyran-3-ones (5) as well as tosyloxy substituted tetrahydropyrans (6) and (7).
