51626-50-7Relevant academic research and scientific papers
Friedel-Crafts alkylation reaction with fluorinated alcohols as hydrogen-bond donors and solvents
Tang, Ren-Jin,Milcent, Thierry,Crousse, Benoit
, p. 10314 - 10317 (2018/03/26)
An effective and clean FC alkylation of indoles and electron-rich arenes with β-nitroalkenes in HFIP was reported. The desired products are formed rapidly in excellent yields under mild conditions without the need for any additional catalysts or reagents. Further, this methodology can be applied to one-pot synthesis of biologically active tryptamine derivatives.
Use of the Pictet-Spengler reaction for the synthesis of 1,4-disubstituted-1,2,3,4-tetrahydro-β-carbolines and 1,4-disubstituted-β-carbolines: formation of γ-carbolines
Kusurkar, Radhika S.,Alkobati, Nabil A.H.,Gokule, Anita S.,Puranik, Vedavati G.
, p. 1654 - 1662 (2008/09/17)
Microwave-assisted conjugate addition of indole on nitro-olefins furnished nitro compounds, which were reduced to tryptamines. Further, by using Pictet-Spengler condensation, new 1,4-disubstituted-1,2,3,4-tetrahydro-β-carbolines were synthesized in diaste
