51631-55-1

Upstream product

• 51632-33-8 (+/-)-2-(4-fluorophenyl)-3-methylbutanoic acid 

Downstream Products

• 51629-64-2 2-(4-Fluoro-phenyl)-3-methyl-butyric acid 4-allyl-benzyl ester 
• 51629-83-5 2-(4-Fluoro-phenyl)-3-methyl-butyric acid 2-methyl-4-oxo-3-prop-2-ynyl-cyclopent-2-enyl ester 

Relevant academic research and scientific papers

Tetrahydronaphthalene derivatives

Tetrahydronaphthalene derivatives of the formula STR1 wherein Y, m, n, R and R1 to R9 are as set forth herein, are described. These compounds have a pronounced calcium-antagonistic and anti-arrhythmic activity and can accordingly be used as medicaments, especially for the control or prevention of angina pectoris, ischaemia, arrhythmias and high blood pressure. The compounds of formula I can be prepared by the amination of a compound of the formula STR2 with a corresponding N-methyl-phenylalkylamine and optional subsequent O-acylation. Compounds of formula II and IV are also described and are within the scope of the invention.