51631-67-5

Basic information

• Product Name: α-methyl 4-methylphenylacetyl chloride
• Synonyms: α-methyl 4-methylphenylacetyl chloride
• CAS NO: 51631-67-5
• Molecular Weight: 182.65
• Mol File: 51631-67-5.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: α-methyl 4-methylphenylacetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: α-methyl 4-methylphenylacetyl chloride(51631-67-5)
• EPA Substance Registry System: α-methyl 4-methylphenylacetyl chloride(51631-67-5)

Safety Data

• Hazardous Substances Data: 51631-67-5(Hazardous Substances Data)

Upstream product

• 622-47-9 4-tolylacetic acid 
• 938-94-3 (R,S)-2-(4'-methylphenyl) propionic acid 

Downstream Products

• 1002357-05-2 N-(2-bromophenyl)-N-methyl-2-p-tolylpropanamide 
• 1002357-08-5 C₁₇H₁₇NO 
• 1092940-31-2 C₁₇H₁₇NO 
• 1430587-49-7 C₂₇H₃₂N₆O₂ 
• 1412457-47-6 1,3-dimethyl-3-(p-tolyl)-1H-pyrrolo[2,3-c]pyridin-2(3H)-one 
• 1364651-68-2 N-methyl-N-(pyridin-2-yl)-2-(p-tolyl)propanamide 
• 1364652-24-3 1,3-dimethyl-3-(p-tolyl)-1H-pyrrolo[3,2-c]pyridin-2(3H)-one 

Relevant articles and documents

Functionalization of α-C(sp3)?H Bonds in Amides Using Radical Translocating Arylating Groups

α-C?H arylation of N-alkylamides using 2-iodoarylsulfonyl radical translocating arylating (RTA) groups is reported. The method allows the construction of α-quaternary carbon centers in amides. Various mono- and disubstituted RTA-groups are applied to the arylation of primary, secondary, and tertiary α-C(sp3)?H-bonds. These radical transformations proceed in good to excellent yields and the cascades comprise a 1,6-hydrogen atom transfer, followed by a 1,4-aryl migration with subsequent SO2 extrusion.

2-Amino-5,6-difluorophenyl-1 H-pyrazole-Directed PdII Catalysis: Arylation of Unactivated β-C(sp3)-H Bonds

Palladium-catalyzed arylation of unactivated β-C(sp3)-H bonds in carboxylic acid derivatives with aryl iodides is described for the first time using 2-amino-5,6-difluorophenyl-1H-pyrazole as an efficient and readily removable directing group. Two fluoro groups are installed at the 5- and 6-position of the anilino moiety in 2-aminophenyl-1H-pyrazole, clearly enhancing the directing ability of the auxiliary. In addition, the protocol employs Cu(OAc)2/Ag3PO4 (1.2/0.3) as additives, evidently reducing the stoichiometric amount of expensive silver salts. Furthermore, this process exhibits high β-site selectivity, compatibility with diverse substrates containing α-hydrogen atoms, and excellent functional group tolerance.

Aza-oxindole synthesis by oxidative coupling of Csp 2-H and Csp3-H centers

A Cu(ii) mediated oxidative Csp2-H and C sp3-H coupling protocol gives access to aza-oxindoles in good to excellent yield in the presence of NaOtBu as base and toluene as solvent. The Royal Society of Chemistry