51632-39-4

Upstream product

• 108-94-1 cyclohexanone 
• 533-68-6 2-bromobutyric acid ethyl ester 

Downstream Products

• 512-16-3 Cyclobutyrol 
• 51632-40-7 2-cyclohex-1-enyl-butyric acid ethyl ester 
• 62479-69-0 ethyl 2-cyclohexylidenebutanoate 
• 858858-34-1 3-cyclohex-1-enyl-pentan-2-one 
• 59-13-2 2-cyclohex-1-enyl-butyric acid amide 
• 20144-46-1 2-cyclohexylidenebutanoic acid 
• 936363-55-2 2-(1-cyclohexen-1-yl)butan-1-ol 

Relevant academic research and scientific papers

Bicyclic β-hydroxytetrahydrofurans as precursors of medium ring keto-lactones

(Chemical Equation Presented) The reaction of a series of cis-fused bicyclic β-hydroxytetrahydrofurans with ruthenium tetraoxide, generated in situ from ruthenium trichloride and sodium periodate, afforded 9- and 10-membered ketolactones in moderate to good yields, in a clean and straightforward fashion. The starting β-hydroxyethers were obtained from the corresponding 3-alkenols by two alternative procedures, depending on their pattern of substitution: (a) epoxidation by dimethyldioxirane, followed by base-catalyzed cyclization of the resulting epoxyalcohol, and (b) thallium trinitrate-mediated cyclization of the 3-alkenols, a method already described by our group.

Some uses of mischmetall in organic synthesis

Mischmetall, an alloy of the light lanthanides, has been used in a variety of organic reactions, either as a coreductant in samarium(II)-mediated reactions (Barbier and Grignard-type reactions, pinacolic coupling reactions) or as the promoter of Reformatsky-type reactions. It has been also employed as the starting material for easy syntheses of lanthanide trihalides, the reactivity of which has been explored in Imamoto and Luche-Fukuzawa reactions and in Mukaiyama aldol reactions.

Synthesis and biological evaluation of cycloalkylidene carboxylic acids as novel effectors of Ras/Raf interaction

The protooncogenes Ras and Raf play important roles in signal transduction pathways regulated by mitogen-activated protein kinases. Mutations of Ras that arrest the protein in its active state are frequently implicated in tumor formation. We used Ras and Raf proteins in the yeast two-hybrid system to search for natural or synthesized substances capable of modulating Ras/Raf interaction by specifically binding to one of the interacting partners. We found that cycloalkylidene carboxylic acids enhanced Ras/Raf interaction by acting on the cysteine-rich domain of Raf. Several analogues of the active substance 2-cyclohexylidene propanoic acid were synthesized and the importance of the semicyclic double bond in the stabilization of Ras/Raf interaction was demonstrated. Variation of the size and the substituents of the cyclic system as well as the length of the carboxylic acid resulted in enhanced Ras/Raf interaction.

Efficient, Low Temperature Reformatsky Reactions of Extended Scope

Laminated zinc/silver-graphite reacts rapidly at low temperatures with α-bromo- and α-chloro-alkanoates and cyclic ketones allowing high yielding and even stereospecific Reformatsky reactions.